Circulating immunoreactive oxytocin during the human menstrual cycle comes from the pituitary and is estradiol dependent.
Circulating immunoreactive oxytocin during the human menstrual cycle comes from the pituitary and is estradiol dependent.
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人类月经周期中循环的免疫反应性催产素来自垂体，并且依赖于雌二醇。
DOI：
10.1210/jcem-68-2-455
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
J. Findlay
中科院分区：
文献类型：
--
作者：
L. Shukovski;D. Healy;J. Findlay
本研究的目的是：1）评估下丘脑和卵巢催产素（OT）对外周血清浓度的相对贡献; 2）确定血清OT和卵巢类固醇浓度之间的关系。研究了4组女性：1）具有自发周期的女性（n = 4）和正常血清雌二醇（E2）、孕酮、LH和FSH水平; 2）接受卵巢过度刺激的体外受精（IVF）患者（n = 8）; 3）接受替代E2和P治疗的激动性卵母细胞受体患者（n = 6）; 4）绝经后女性（n = 21）。在IVF组中，在月经周期期间每天从正常和无排卵妇女收集外周血清样品，并在排卵前6天收集外周血清样品。血清免疫反应性OT经Sep-Pak提取后用特异性RIA测定，测定灵敏度为0.6pmol/L。正常月经周期妇女的血清OT在卵泡期升高，在LH峰后1天达到峰值，在黄体期降低[第7、16和21天，分别为10.7 +/- 3.5（平均值+/- SE）、25.7 +/- 5.7和13.2 +/- 2.5 pmol/L; P <0.05]。IVF患者排卵前血清OT水平高于自发性周期的妇女，但低于无排卵期妇女，后者在E2/孕酮替代治疗的第13天达到峰值（49.1 +/- 9.6 pmol/L; P <0.05）。在周期的第一部分，血清OT与血清E2值呈正相关（r = 0.68，正常妇女; r = 0.91，卵母细胞受体）（P <0.01）。绝经后妇女血清OT与E_2亦呈显著正相关（r = 0.83）。我们的结论是，血清OT之前和周围的时间排卵主要来自垂体，而不是从卵巢，是E2依赖。
The aims of this study were to 1) evaluate the relative contributions of hypothalamic and ovarian oxytocin (OT) to peripheral serum concentrations and 2) determine the relationship between serum OT and ovarian steroid concentrations. Four groups of women were studied: 1) women with spontaneous cycles (n = 4) and normal serum estradiol (E2), progesterone, LH, and FSH levels; 2) in vitro fertilization (IVF) patients (n = 8) undergoing ovarian hyperstimulation; 3) agonadal oocyte-recipient patients (n = 6) receiving replacement E2 and P therapy; and 4) postmenopausal women (n = 21). Peripheral serum samples were collected daily during a menstrual cycle from the normal and agonadal women and for 6 days before ovulation in the IVF group. Serum immunoreactive OT was measured by specific RIA after Sep-Pak extraction; the assay sensitivity was 0.6 pmol/L. Serum OT in the women with normal cycles increased during the follicular phase, reaching a peak 1 day after the LH surge, and decreased in the luteal phase [days 7, 16, and 21, 10.7 +/- 3.5 (mean +/- SE), 25.7 +/- 5.7, and 13.2 +/- 2.5 pmol/L, respectively; P less than 0.05]. Serum OT levels were higher in IVF patients before ovulation than in women with spontaneous cycles, but lower than those in the agonadal women, who had a peak value (49.1 +/- 9.6 pmol/L; P less than 0.05) on day 13 of E2/progesterone replacement therapy. Serum OT was positively correlated (r = 0.68, normal women; r = 0.91, oocyte recipients) with serum E2 values during the first part of the cycle (P less than 0.01). A similar positive correlation between serum OT and E2 was found in the postmenopausal women (r = 0.83). We conclude that serum OT before and around the time of ovulation comes mainly from the pituitary, and not from the ovary, and is E2 dependent.
从慢性肾功能衰竭患者的血浆中高压液相色谱分离催产素/精氨酸催产素样肽。
DOI：
10.1210/jcem-60-4-644
发表时间：
1985
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Amico,JA;DollJr,RB;Finn,FM;Ervin,MG;Leake,RD;Fisher,DA;Robinson,AG
通讯作者：
Robinson,AG
影响因子：
5.8
作者：
AMICO, JA;SEIF, SM;ROBINSON, AG
通讯作者：
ROBINSON, AG