Impact of adjuvant chemotherapy on the overall survival of patients with resectable bulky small cell neuroendocrine cervical cancer: a JSGO-JSOG joint study.
Impact of adjuvant chemotherapy on the overall survival of patients with resectable bulky small cell neuroendocrine cervical cancer: a JSGO-JSOG joint study.
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DOI：
10.3802/jgo.2023.34.e4
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发表时间：
2023-01
影响因子：
3.9
通讯作者：
Mikami M
中科院分区：
文献类型：
--
作者：
Seino M;Nagase S;Ohta T;Yamagami W;Ebina Y;Kobayashi Y;Tabata T;Kaneuchi M;Enomoto T;Mikami M
本研究的目的是回顾小细胞神经内分泌宫颈癌（SCNEC）的临床病理特点，并确定最佳治疗方法。日本妇科肿瘤学会对2004年至2015年在日本妇产科学会妇科肿瘤登记处登记的scnec进行了回顾性队列研究。所有病例均由2008年国际妇产科联合会（国际癌症控制联盟第7版）修改统一。2004 - 2015年登记的SCNEC患者822例，占所有宫颈癌病例的1.1%（822/73,698）。T1b2组淋巴结和远处转移率（分别为38.9%和13.7%）显著高于T1b1组（分别为14.2%和4.4%）（p<0.01）。在IB2和T1bN1M0 SCNEC中，手术加化疗的5年生存率明显高于手术加放疗/同步放化疗（p<0.01）。与小于4cm的SNCEC肿瘤相比，小于4cm的SNCEC肿瘤有更高的淋巴结和远处转移率。辅助化疗，而不是放疗，可能改善T1bN1M0 SCNEC术后预后。小细胞神经内分泌宫颈癌（SNCEC）肿瘤体积小于4cm时，淋巴结和远处转移的发生率高于小于4cm的肿瘤。在IB2和T1bN1M0 SCNEC中，辅助化疗的总生存率明显高于辅助放疗。辅助化疗，而不是放疗，可能改善T1bN1M0 SCNEC术后预后。
The aim of this study was to review the clinicopathological characteristics of small cell neuroendocrine cervical cancer (SCNEC) and to identify the optimal treatment. The Japanese Society of Gynecologic Oncology conducted a retrospective cohort study of SCNECs enrolled in the Gynecological Tumor Registry of the Japan Society of Obstetrics and Gynecology between 2004 and 2015. All cases were modified and unified by International Federation of Gynecology and Obstetrics 2008 (Union for International Cancer Control 7th edition). There were 822 registered patients diagnosed with SCNEC from 2004 to 2015 which comprised 1.1% (822/73,698) of all uterine cervical cancer cases. Rates of lymph-node and distant metastasis were significantly higher in T1b2 (38.9% and 13.7%, respectively) than T1b1 (14.2% and 4.4%, respectively) (p<0.01). In IB2 and T1bN1M0 SCNEC, the 5-year survival rate with surgery followed by chemotherapy was significantly higher than that with surgery followed by radiation therapy/concurrent chemoradiation therapy (p<0.01). SNCEC tumors >4 cm in size had greater rates of lymph-node and distant metastasis when compared with tumors ≤4 cm. Adjuvant chemotherapy, rather than radiotherapy, may improve prognosis after surgery in T1bN1M0 SCNEC. Small cell neuroendocrine cervical cancer (SNCEC) tumors >4 cm in size had greater rates of lymph-node and distant metastasis when compared with tumors ≤4 cm. In IB2 and T1bN1M0 SCNEC, the overall survival with adjuvant chemotherapy was significantly higher than that with adjuvant radiotherapy. Adjuvant chemotherapy, rather than radiotherapy, may improve prognosis after surgery in T1bN1M0 SCNEC.
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