Methylglyoxal (MG) and cerebro-renal interaction: does long-term orally administered MG cause cognitive impairment in normal Sprague-Dawley rats?
Methylglyoxal (MG) and cerebro-renal interaction: does long-term orally administered MG cause cognitive impairment in normal Sprague-Dawley rats?
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DOI：
10.3390/toxins6010254
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发表时间：
2014-01-07
期刊：
影响因子：
4.2
通讯作者：
Nakayama M
中科院分区：
文献类型：
--
作者：
Watanabe K;Okada K;Fukabori R;Hayashi Y;Asahi K;Terawaki H;Kobayashi K;Watanabe T;Nakayama M
甲基乙二醛（MG）是一种高活性的α-二羰基化合物，是尿毒症毒素之一。最近的临床研究表明，认知功能障碍（CI）与血浆MG水平和肾功能不全的存在密切相关。因此，本研究旨在探讨MG是否是CI发展的直接原因。8周龄雄性SD大鼠随机分为对照组（n = 9）和MG组（n = 10; 0.5%MG饮用水），正常饮食喂养12个月。在早期（4-6月龄）和晚期（7-12月龄）通过两项行为测试（物体探索测试和径向臂迷宫测试）评估认知功能。在研究结束时，MG组的血清MG显著升高（495.8 ± 38.1对244.8 ± 28.2 nM; p < 0.001）。在研究过程中，各组的认知功能没有差异。两组之间的氧化应激指标无时程差异，而抗氧化剂，如谷胱甘肽过氧化物酶和超氧化物歧化酶的活性显着增加MG组相比，对照组。肾功能正常的大鼠长期给予MG不会引起CI。在该模型中，全身抗氧化系统的平衡激活可抵消MG的毒性。MG对CI的发病意义需要进一步研究。
Methylglyoxal (MG), one of the uremic toxins, is a highly reactive alpha-dicarbonyl compound. Recent clinical studies have demonstrated the close associations of cognitive impairment (CI) with plasma MG levels and presence of kidney dysfunction. Therefore, the present study aims to examine whether MG is a direct causative substance for CI development. Eight-week-old male Sprague-Dawley (SD) rats were divided into two groups: control (n = 9) and MG group (n = 10; 0.5% MG in drinking water), and fed a normal diet for 12 months. Cognitive function was evaluated by two behavioral tests (object exploration test and radial-arm maze test) in early (4–6 months of age) and late phase (7–12 months of age). Serum MG was significantly elevated in the MG group (495.8 ± 38.1 vs. 244.8 ± 28.2 nM; p < 0.001) at the end of study. The groups did not differ in cognitive function during the course of study. No time-course differences were found in oxidative stress markers between the two groups, while, antioxidants such as glutathione peroxidase and superoxide dismutase activities were significantly increased in the MG group compared to the control. Long-term MG administration to rats with normal kidney function did not cause CI. A counter-balanced activation of the systemic anti-oxidant system may offset the toxicity of MG in this model. Pathogenetic significance of MG for CI requires further investigation.
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影响因子：
5.4
作者：
Chen, Xianguang;Mori, Takefumi;Guo, Qi;Hu, Chunyan;Ohsaki, Yusuke;Yoneki, Yoshimi;Zhu, Wanjun;Jiang, Yue;Endo, Satoshi;Nakayama, Keisuke;Ogawa, Susumu;Nakayama, Masaaki;Miyata, Toshio;Ito, Sadayoshi
通讯作者：
Ito, Sadayoshi
影响因子：
5
作者：
Benzie, IFF
通讯作者：
Benzie, IFF
影响因子：
2.9
作者：
Di Loreto, S;Caracciolo, V;Amicarelli, F
通讯作者：
Amicarelli, F
影响因子：
3.7
作者：
Falone, Stefano;D'Alessandro, Antonella;Amicarelli, Fernanda
通讯作者：
Amicarelli, Fernanda
DOI：
10.1016/j.biocel.2007.07.019
发表时间：
2008-01-01
影响因子：
4
作者：
Di Loreto, Silvia;Zimmitti, Vincenzo;Arnicarelli, Fernanda
通讯作者：
Arnicarelli, Fernanda