Tuberculosis risk factors among tuberculosis patients in Kampala, Uganda: implications for tuberculosis control.
Tuberculosis risk factors among tuberculosis patients in Kampala, Uganda: implications for tuberculosis control.
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乌干达坎帕拉的结核病患者的结核病风险因素：对控制结核的影响。
DOI：
10.1186/s12889-015-1376-3
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发表时间：
2015-01-21
影响因子：
4.5
通讯作者：
Okwera A
中科院分区：
文献类型：
--
作者：
Kirenga BJ;Ssengooba W;Muwonge C;Nakiyingi L;Kyaligonza S;Kasozi S;Mugabe F;Boeree M;Joloba M;Okwera A
在大多数结核病负担高的国家，结核病发病率下降缓慢。了解不同结核病危险因素的流行情况有助于扩大结核病控制战略。然而，除人类免疫缺陷病毒(艾滋病毒)外，乌干达对其他结核病危险因素的流行率研究很少。我们的目标是确定不同结核病危险因素的流行率和乌干达坎帕拉结核病患者的结核病表现。我们评估了365名成人结核病患者，并使用描述性统计方法总结了他们的社会人口学、临床、放射学、痰分支杆菌学和结核病危险因素(艾滋病毒、糖尿病、结核病接触、饮酒、吸烟、贫困和过度拥挤)数据。共有158名患者(43.3%)为男性，中位年龄为29岁(IQR28-30)。大多数患者(89.2%)为肺结核，86.9%为初治，13.2%为复治。38.5%的患者出现消瘦(即体重指数为18.5g/m2)，63%的患者出现咳嗽。躯体症状(发热、食欲不振、盗汗和体重减轻)的报告比例为32.1%。大多数患者(78.6%)表现为非空洞肺实质病变(浸润性、结节、肿块)，但35.2%的患者有空洞性病变。胸膜病变的发生率为19.3%。涂片镜检和培养阳性(与治疗月份无关)分别为52.7%和36.5%。21.1%的患者检测到任何耐药，而6.3%的患者检测到多药耐药(MDR)结核病，定义为对利福平和异烟肼的耐药性。所有MDR患者均为新发患者。结核病危险因素患病率依次为：HIV 41.4%，糖尿病5.4%，密切接触11.5%，家族史17.5%，吸烟26.37%，贫困39.5%，过度拥挤57.3%，饮酒50.7%。过度拥挤增加了涂阳患病率，患病率为1.2 2，p = 为0.0 9，但所有研究的其他危险因素均不影响临床、放射学和分枝杆菌研究患者的特征。在乌干达坎帕拉的结核病患者中，已知的结核病危险因素的流行率很高。有针对性地降低其流行率可能会导致该国更好地控制结核病。结核病，危险因素，乌干达。
Slow decline in the incidence of tuberculosis (TB) has been observed in most high TB burden countries. Knowledge of the prevalence of different TB risk factors can help expand TB control strategies. However with the exception of Human Immunodeficiency Virus (HIV) the prevalence of the other TB risk factors are poorly studied in Uganda. We aimed to determine the prevalence of different TB risk factors and TB disease presentation among TB patients in Kampala Uganda. We assessed 365 adult TB patients and used descriptive statistics to summarize their socio-demographic, clinical, radiological, sputum mycobacteriology and TB risk factors (HIV, diabetes, TB contact, alcohol use, tobacco smoking, poverty and overcrowding) data. A total of 158 (43.3%) patients were male and the median age was 29 (IQR 28–30). Majority of the patients (89.2%) had pulmonary TB, 86.9% were new and 13.2% were retreatment. Wasting (i.e. body mass index of <18.5 kg/m2) was found in 38.5% of the patients and 63% presented with cough. Constitutional symptoms (fever, anorexia, night sweats and weight loss) were reported by 32.1%. Most patients (78.6%) presented with non-cavity lung parenchyma disease (infiltrates, nodules, masses) but 35.2% had cavity disease. Pleural disease was detected in 19.3% of patients. Positive smear microscopy and culture (irrespective of month of treatment) was found in 52.7% and 36.5% of patients respectively. Any drug resistance was detected in 21.1% of patients while multidrug resistance (MDR) TB defined as resistance to rifampicin and isoniazid was detected in 6.3% of patients. All MDR patients were new patients. The prevalence of TB risk factors were as follows: HIV 41.4%, diabetes 5.4%, close contact 11.5%, family history 17.5%, smoking 26.37%, poverty 39.5%, overcrowding 57.3% and alcohol use 50.7%. Overcrowding increased smear positive rate, prevalence ratio 1.22, p = 0.09 but all the other studied risk factors did not affect clinical, radiological and mycobacteriological study patient characteristics. Among TB patients in Kampala, Uganda, there is high prevalence of the known TB risk factors. Targeting reducing their prevalence may lead to better TB control in the country. Tuberculosis, risk factors, Uganda.
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高艾滋病毒患病率的结核病流行病学和症状疾病的诊断增加。
影响因子：
15.8
作者：
Corbett, Elizabeth L.;Bandason, Tsitsi;Cheung, Yin Bun;Munyati, Shungu;Godfrey-Faussett, Peter;Hayes, Richard;Churchyard, Gavin;Butterworth, Anthony;Mason, Peter
通讯作者：
Mason, Peter
影响因子：
4.3
作者：
Narasimhan P;Wood J;Macintyre CR;Mathai D
通讯作者：
Mathai D
影响因子：
3.7
作者：
Lukoye, Deus;Adatu, Francis;Joloba, Moses L.
通讯作者：
Joloba, Moses L.
影响因子：
24.3
作者：
Creswell, J.;Raviglione, M.;Loennroth, K.
通讯作者：
Loennroth, K.
DOI：
10.1183/09031936.00070812
发表时间：
2013-01
期刊：
The European respiratory journal
影响因子：
--
作者：
Fox GJ;Barry SE;Britton WJ;Marks GB
通讯作者：
Marks GB