Introducing descending control of nociception: a measure of diffuse noxious inhibitory controls in conscious animals.
Introducing descending control of nociception: a measure of diffuse noxious inhibitory controls in conscious animals.
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DOI：
10.1097/j.pain.0000000000002203
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发表时间：
2021-07-01
期刊：
影响因子：
7.4
通讯作者：
Porreca F
中科院分区：
文献类型：
--
作者：
Bannister K;Kucharczyk MW;Graven-Nielsen T;Porreca F
自从Le Bars等人在1979年详细描述了“会聚背角神经元的活动可以被施加到身体各个部位的伤害性刺激强烈抑制”21以来，弥漫性伤害性抑制控制（DNIC）为基础研究提供了一个独特的下行抑制通路功能的替代测量。这种疼痛抑制疼痛样现象最初是在麻醉的啮齿动物中描述的，其中可以将功能性DNIC量化为施加条件刺激后脊髓会聚神经元的外周诱发活动的减少。2，21有趣的是，在有意识的人类中也观察到了这种条件反射时自然发生的镇痛作用。13，22，33条件性疼痛调节（CPM）现在用于描述DNIC的人类对应物，35 CPM范例旨在评估DNIC作为下行抑制系统的替代测量的功效。[9]由于DNIC到CPM的翻译值可以通过人类CPM加工的预测质量来衡量，因此，对测量行为动物中条件激活的下行抑制控制的表达状态的关注也就不足为奇了。11，12，32，37越来越多的人类和动物DNIC和CPM研究（图1）强调了在描述这种效应时及时考虑适当术语的必要性。在认识到这一事实，只有DNIC样的行为，到目前为止，可以在清醒的动物中进行测量，它是不合适的，因为动物的反应是非语言的，使用CPM指减少疼痛相关的行为在临床前研究，我们建议，在清醒的动物条件反射下行调节通路激活的实验量化被称为伤害性感受（DCN）的下行控制。
Ever since Le Bars et al. 21 detailed in 1979 that “the activity of convergent dorsal horn neurons could be powerfully inhibited by noxious stimuli applied to various parts of the body,” 21 diffuse noxious inhibitory controls (DNIC) have provided basic research a proxy measure of the functionality of a unique descending inhibitory pathway. This pain inhibits pain–like phenomenon was originally described in anaesthetised rodents, where it is possible to quantify functional DNIC as a decrease in the peripherally evoked activity of spinal convergent neurons after application of a conditioning stimulus. 2, 21 Interestingly, such naturally occurring analgesia upon conditioning is also observed in conscious humans. 13, 22, 33 Conditioned pain modulation (CPM) is now used to describe the human counterpart of DNIC, 35 and CPM paradigms are purported to assess the efficacy of DNIC as a surrogate measure of a descending inhibitory system. 9 Since the translational value of DNIC to CPM may be gauged by the predictive quality of human CPM processing, it is unsurprising that a focus on measuring the expression status of conditioning-activated descending inhibitory controls in behaving animals is coming to the fore. 11, 12, 32, 37 An increasing number of human and animal DNIC and CPM studies (Fig. 1) highlight the timely need for consideration of what the appropriate terminology is when describing this effect. In recognition of the fact that only DNIC-like behaviours can so far be measured in wakeful animals, and that it is not appropriate to use CPM to refer to a reduction in pain-related behaviours in preclinical research since animal responses are nonverbal, we recommend that the experimental quantification of descending modulatory pathway activation upon conditioning in wakeful animals be referred to as descending control of nociception (DCN).
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影响因子：
3.6
作者：
Cummins, Tatum M.;Kucharczyk, Mateusz M.;Bannister, Kirsty
通讯作者：
Bannister, Kirsty
影响因子：
3.6
作者：
Graven-Nielsen, T.;Izumi, M.;Arendt-Nielsen, L.
通讯作者：
Arendt-Nielsen, L.
影响因子：
2.7
作者：
Da Silva JT;Zhang Y;Asgar J;Ro JY;Seminowicz DA
通讯作者：
Seminowicz DA
影响因子：
14.5
作者：
DEBROUCKER, T;CESARO, P;LEBARS, D
通讯作者：
LEBARS, D
影响因子：
7.4
作者：
CERVERO, F;IGGO, A;OGAWA, H
通讯作者：
OGAWA, H