Diffuse noxious inhibitory controls and brain networks are modulated in a testosterone-dependent manner in Sprague Dawley rats.
Diffuse noxious inhibitory controls and brain networks are modulated in a testosterone-dependent manner in Sprague Dawley rats.
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DOI：
10.1016/j.bbr.2018.04.055
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发表时间：
2018-09-03
影响因子：
2.7
通讯作者：
Seminowicz DA
中科院分区：
文献类型：
--
作者：
Da Silva JT;Zhang Y;Asgar J;Ro JY;Seminowicz DA
弥漫性有害抑制控制（DNIC）涉及内源性疼痛调节，已被研究作为观察到的男性和女性疼痛调节差异的潜在机制，尽管文献显示矛盾的结果。我们使用辣椒素诱导的DNIC行为实验和静息状态功能磁共振成像（rsfMRI）来评估睾酮对大鼠疼痛调节和相关脑回路的影响。我们假设睾酮是DNIC通过增加下行疼痛调节导致有效疼痛抑制所必需的。在雄性、雌性和去兰科（GDX）雄性大鼠前爪注射辣椒素诱导DNIC，观察后爪机械阈值。通过辣椒素注射前后rsfMRI扫描，分析DNIC对脑导水管周围灰质（PAG）、前扣带皮层（ACC）和伏隔核（NAc）与全脑连通性的影响。男性DNIC的强度高于女性和GDX男性。男性PAG与前边缘皮质（PrL）、ACC和脑岛的连通性比女性和GDX男性强，而女性和GDX男性的右侧ACC、海马和丘脑之间的连通性增加。GDX男性的右ACC与NAc、右NAc与PrL、ACC、脑岛和丘脑之间的连通性也更强。我们的研究结果表明，睾酮在加强内源性疼痛抑制系统中起着关键作用，而在缺乏睾酮的情况下，与奖励和情绪相关的回路更强烈地被招募。
Diffuse noxious inhibitory control (DNIC), which involves endogenous pain modulation, has been investigated as a potential mechanism for the differences in pain modulation observed between men and women, though the literature shows contradictory findings. We used a capsaicin-induced DNIC behavioral assay and resting state functional magnetic resonance imaging (rsfMRI) to assess the effect of testosterone on pain modulation and related brain circuitry in rats. We hypothesized that testosterone is required for DNIC that leads to efficient pain inhibition by increasing descending pain modulation. Male, female, and orchidectomized (GDX) male rats had a capsaicin injection into the forepaw to induce DNIC and mechanical thresholds were observed on the hindpaw. rsfMRI scans were acquired before and after capsaicin injection to analyze the effects of DNIC on periaqueductal gray (PAG), anterior cingulate cortex (ACC) and nucleus accumbens (NAc) connectivity to the whole brain. The strength of DNIC was higher in males compared to females and GDX males. PAG connectivity with prelimbic cortex (PrL), ACC and insula was stronger in males compared to females and GDX males, whereas females and GDX males had increased connectivity between the right ACC, hippocampus and thalamus. GDX males also showed a stronger connectivity between right ACC and NAc, and right NAc with PrL, ACC, insula and thalamus. Our findings suggest that testosterone plays a key role in reinforcing the endogenous pain inhibitory system, while circuitries related to reward and emotion are more strongly recruited in the absence of testosterone.
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影响因子：
16.2
作者：
Baliki, Marwan N.;Geha, Paul Y.;Fields, Howard L.;Apkarian, A. Vania
通讯作者：
Apkarian, A. Vania
影响因子：
2.7
作者：
Bulls HW;Freeman EL;Anderson AJ;Robbins MT;Ness TJ;Goodin BR
通讯作者：
Goodin BR
影响因子：
5
作者：
Itomi, Yasuo;Tsukimi, Yasuhiro;Kawamura, Toru
通讯作者：
Kawamura, Toru
影响因子：
7.4
作者：
Gilchrist, HD;Allard, BL;Simone, DA
通讯作者：
Simone, DA
影响因子：
16.2
作者：
Eippert, Falk;Bingel, Ulrike;Buechel, Christian
通讯作者：
Buechel, Christian