Real time and delayed effects of subcortical low intensity focused ultrasound.
Real time and delayed effects of subcortical low intensity focused ultrasound.
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DOI：
10.1038/s41598-021-85504-y
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发表时间：
2021-03-17
影响因子：
4.6
通讯作者：
Monti MM
中科院分区：
文献类型：
--
作者：
Cain JA;Visagan S;Johnson MA;Crone J;Blades R;Spivak NM;Shattuck DW;Monti MM
Deep brain nuclei are integral components of large-scale circuits mediating important cognitive and sensorimotor functions. However, because they fall outside the domain of conventional non-invasive neuromodulatory techniques, their study has been primarily based on neuropsychological models, limiting the ability to fully characterize their role and to develop interventions in cases where they are damaged. To address this gap, we used the emerging technology of non-invasive low-intensity focused ultrasound (LIFU) to directly modulate left lateralized basal ganglia structures in healthy volunteers. During sonication, we observed local and distal decreases in blood oxygenation level dependent (BOLD) signal in the targeted left globus pallidus (GP) and in large-scale cortical networks. We also observed a generalized decrease in relative perfusion throughout the cerebrum following sonication. These results show, for the first time using functional MRI data, the ability to modulate deep-brain nuclei using LIFU while measuring its local and global consequences, opening the door for future applications of subcortical LIFU.
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影响因子：
--
作者：
Agnesi, Filippo;Johnson, Matthew D;Vitek, Jerrold L
通讯作者：
Vitek, Jerrold L
影响因子：
5.7
作者：
Groves, Adrian R.;Chappell, Michael A.;Woolrich, Mark W.
通讯作者：
Woolrich, Mark W.
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
DOI：
10.1111/nyas.12110
发表时间：
2013-01-01
期刊：
YEAR IN COGNITIVE NEUROSCIENCE
影响因子：
--
作者：
Bestmann, Sven;Feredoes, Eva
通讯作者：
Feredoes, Eva
DOI：
10.1007/978-1-59745-360-8_9
发表时间：
2008-01-01
期刊：
DEEP BRAIN STIMULATION IN NEUROLOGICAL AND PSYCHIATRIC DISORDERS
影响因子：
--
作者：
Jech, Robert
通讯作者：
Jech, Robert