The potential of optofluidic biolasers.
The potential of optofluidic biolasers.
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DOI:
10.1038/nmeth.2805
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发表时间:
2014-02
期刊:
影响因子:
48
通讯作者:
Yun, Seok-Hyun
中科院分区:
文献类型:
--
作者:
Fan, Xudong;Yun, Seok-Hyun
An optofluidic bio-laser integrates biological materials into the gain medium while forming an optical cavity in the fluidic environment, either on a microfluidic chip or within a biological system. The laser emission has characteristics fundamentally different from conventional fluorescence emission. It can be highly sensitive to a specific molecular change in the gain medium as the light-matter interaction is amplified by the resonance in the cavity. The enhanced sensitivity can be used to probe and quantify the underlying biochemical and biological processes in vitro in a microfluidic device, in situ in a cell (cytosol), or in vivo in a live organism. Here we describe the principle of the optofluidic bio-laser, review its recent progress and provide an outlook of this emerging technology.
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