A Comprehensive Examination of Severely Ill ME/CFS Patients.
A Comprehensive Examination of Severely Ill ME/CFS Patients.
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DOI：
10.3390/healthcare9101290
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发表时间：
2021-09-29
期刊：
影响因子：
--
通讯作者：
Davis RW
中科院分区：
文献类型：
--
作者：
Chang CJ;Hung LY;Kogelnik AM;Kaufman D;Aiyar RS;Chu AM;Wilhelmy J;Li P;Tannenbaum L;Xiao W;Davis RW
据估计，四分之一的肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）患者受到该疾病的严重影响，这些足不出户或卧床不起的患者目前尚未得到充分研究。在这里，我们报告了一组重症患者和健康对照者的症状和临床实验室检查的综合检查。患者生活质量的大幅下降与临床抑郁呈负相关。最棘手的症状包括疲劳（85%）、疼痛（65%）、认知障碍（50%）、站立不耐受（45%）、睡眠障碍（35%）、运动后不适（30%）和神经感觉障碍（30%）。睡眠概况和认知测试显示出明显的损伤。在患者中观察到较低的早晨皮质醇水平和其昼夜节律的改变，抗体和抗原测量显示没有常见病毒或细菌病原体急性感染的证据。这些结果突出了开发ME/CFS分子诊断方法的迫切需要。此外，长冠状病毒与ME/CFS在症状上有着惊人的相似性，这表明对ME/CFS机制和治疗的研究可能有助于长冠状病毒的预防和治疗，反之亦然。
One in four myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) patients are estimated to be severely affected by the disease, and these house-bound or bedbound patients are currently understudied. Here, we report a comprehensive examination of the symptoms and clinical laboratory tests of a cohort of severely ill patients and healthy controls. The greatly reduced quality of life of the patients was negatively correlated with clinical depression. The most troublesome symptoms included fatigue (85%), pain (65%), cognitive impairment (50%), orthostatic intolerance (45%), sleep disturbance (35%), post-exertional malaise (30%), and neurosensory disturbance (30%). Sleep profiles and cognitive tests revealed distinctive impairments. Lower morning cortisol level and alterations in its diurnal rhythm were observed in the patients, and antibody and antigen measurements showed no evidence for acute infections by common viral or bacterial pathogens. These results highlight the urgent need of developing molecular diagnostic tests for ME/CFS. In addition, there was a striking similarity in symptoms between long COVID and ME/CFS, suggesting that studies on the mechanism and treatment of ME/CFS may help prevent and treat long COVID and vice versa.
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