A Comprehensive Analysis Identified Hub Genes and Associated Drugs in Alzheimer's Disease.
A Comprehensive Analysis Identified Hub Genes and Associated Drugs in Alzheimer's Disease.
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DOI：
10.1155/2021/8893553
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发表时间：
2021
影响因子：
--
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Jing Q;Zhang H;Sun X;Xu Y;Cao S;Fang Y;Zhao X;Li C
Alzheimer's disease (AD) is the most common neurodegenerative disease among the elderly and has become a growing global health problem causing great concern. However, the pathogenesis of AD is unclear and no specific therapeutics are available to provide the sustained remission of the disease. In this study, we used comprehensive bioinformatics to determine 158 potential genes, whose expression levels changed between the entorhinal and temporal lobe cortex samples from cognitively normal individuals and patients with AD. Then, we clustered these genes in the protein-protein interaction analysis and identified six significant genes that had more biological functions. Besides, we conducted a drug-gene interaction analysis of module genes in the drug-gene interaction database and obtained 26 existing drugs that might be applied for the prevention and treatment of AD. In addition, a predictive model was built based on the selected genes using different machine learning algorithms to identify individuals with AD. These findings may provide new insights into AD therapy.
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影响因子：
14.9
作者：
Ritchie ME;Phipson B;Wu D;Hu Y;Law CW;Shi W;Smyth GK
通讯作者：
Smyth GK
影响因子：
48
作者：
Li T;Wernersson R;Hansen RB;Horn H;Mercer J;Slodkowicz G;Workman CT;Rigina O;Rapacki K;Stærfeldt HH;Brunak S;Jensen TS;Lage K
通讯作者：
Lage K
DOI：
10.1111/j.1532-5415.1995.tb07401.x
发表时间：
1995-11-01
影响因子：
6.3
作者：
JOST, BC;GROSSBERG, GT
通讯作者：
GROSSBERG, GT
影响因子：
25
作者：
Busche, Marc Aurel;Kekus, Maja;Konnerth, Arthur
通讯作者：
Konnerth, Arthur
影响因子：
--
作者：
Maag JLV
通讯作者：
Maag JLV