The cerebral hemodynamic response to phonetic changes of speech in preterm and term infants: The impact of postmenstrual age.
The cerebral hemodynamic response to phonetic changes of speech in preterm and term infants: The impact of postmenstrual age.
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DOI：
10.1016/j.nicl.2018.05.005
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Takahashi T
中科院分区：
文献类型：
--
作者：
Arimitsu T;Minagawa Y;Yagihashi T;O Uchida M;Matsuzaki A;Ikeda K;Takahashi T
高级脑功能障碍，如语言延迟，是早产儿的主要问题。早产儿认知发展的大脑基质仍然难以捉摸，部分原因是方法有限。本研究的重点是使用近红外光谱脑功能的血流动力学反应模式。具体而言，该研究调查了早产儿（n = 60）和足月儿（n = 20）的语音变化和大脑半球听觉区的专业化引起的血流动力学反应模式的妊娠差异。80例胎龄在26 ~ 41周的新生儿在33 ~ 41周的经后年龄（PMA）进行了测试。我们分析了血流动力学反应模式的音位和韵律对比的多个渠道的颞区和偏侧指数的听觉区。小于39周PMA的早产儿表现出明显的非典型血流动力学模式，具有倒置的反应形状。血流动力学反应的典型性评分与PMA呈显著正相关。从39周的PMA早产儿的偏侧化指数表现出类似于足月儿的韵律变化的倾向优势。我们提供了新的证据表明，血流动力学调节的变化和功能系统的音素和韵律处理早产儿赶上他们的预计预产期。本文对80例早产儿和足月儿进行了语音刺激的血流动力学检查。fNIRS测量半球专业化的音位和韵律的对比。一些早产儿表现出不典型的血流动力学与倒置的反应形状。月经后年龄与血流动力学模式和功能偏侧有关。早产儿在预产期前的功能性血流动力学调节。
Higher brain dysfunction, such as language delay, is a major concern among preterm infants. Cerebral substrates of cognitive development in preterm infants remain elusive, partly because of limited methods. The present study focuses on hemodynamic response patterns for brain function by using near-infrared spectroscopy. Specifically, the study investigates gestational differences in the hemodynamic response pattern evoked in response to phonetic changes of speech and cerebral hemispheric specialization of the auditory area in preterm infants (n = 60) and term infants (n = 20). Eighty neonates born between 26 and 41 weeks of gestational age (GA) were tested from 33 to 41 weeks of postmenstrual age (PMA). We analyzed the hemodynamic response pattern to phonemic and prosodic contrasts for multiple channels on temporal regions and the laterality index of the auditory area. Preterm infants younger than 39 weeks of PMA showed significantly atypical hemodynamic patterns, with an inverted response shape. Partial correlation analysis of the typicality score of hemodynamic response revealed a significant positive correlation with PMA. The laterality index of preterm infants from 39 weeks of PMA demonstrated a tendency rightward dominance for prosodic changes similar to term infants. We provide new evidence that alterations in hemodynamic regulation and the functional system for phonemic and prosodic processing in preterm infants catch up by their projected due dates. Hemodynamic responses to speech were examined in 80 preterm and term neonates. fNIRS measured hemispheric specialization to phonemic and prosodic contrasts. Some preterm infants showed atypical hemodynamics with an inverted response shape. Postmenstrual age was related to hemodynamic patterns and functional lateralization. Functional hemodynamic regulation of preterm infants caught up by the expected dates.
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影响因子：
3.8
作者：
Arimitsu T;Uchida-Ota M;Yagihashi T;Kojima S;Watanabe S;Hokuto I;Ikeda K;Takahashi T;Minagawa-Kawai Y
通讯作者：
Minagawa-Kawai Y
影响因子：
3.5
作者：
Kohno, Satoru;Miyai, Ichiro;Shimizu, Koji
通讯作者：
Shimizu, Koji
DOI：
10.1073/pnas.0806530105
发表时间：
2008-09-16
影响因子：
11.1
作者：
Gervain, Judit;Macagno, Francesco;Mehler, Jacques
通讯作者：
Mehler, Jacques
影响因子：
2.6
作者：
Bisiacchi, Patrizia Silvia;Mento, Giovanni;Suppiej, Agnese
通讯作者：
Suppiej, Agnese
影响因子：
5.3
作者：
Boynton, GM;Engel, SA;Heeger, DJ
通讯作者：
Heeger, DJ