Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis and treatment of human respiratory syncytial virus, parainfluenza virus, metapneumovirus, rhinovirus, and coronavirus.
Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis and treatment of human respiratory syncytial virus, parainfluenza virus, metapneumovirus, rhinovirus, and coronavirus.
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DOI：
10.1093/cid/cis844
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Ljungman P
中科院分区：
文献类型：
--
作者：
Hirsch HH;Martino R;Ward KN;Boeckh M;Einsele H;Ljungman P
呼吸道病毒已被认为是白血病患者和接受造血干细胞移植患者发病和死亡的重要原因。下呼吸道感染和致死性结局的风险似乎取决于特定社区获得性呼吸道病毒的内在毒力以及患者、基础疾病及其治疗的特定因素。社区获得性呼吸道病毒（CARV）感染已被认为是白血病患者和接受造血干细胞移植（HSCT）患者发病和死亡的重要原因。进展为下呼吸道感染伴肺炎和呼吸衰竭的临床和放射学体征似乎取决于特定CARV的内在毒力以及患者、基础疾病及其治疗的特定因素。为了更好地定义白血病和HSCT患者中CARV的知识现状，并改善CARV诊断和管理，2011年第四届欧洲白血病感染会议（ECIL-4）的工作组审查了CARV的文献，对可用证据的质量进行了分级，并根据美国传染病学会分级系统提出了建议。由于流感病毒和腺病毒在筛查、临床表现和治疗方面的差异，ECIL-4建议对流感病毒和腺病毒以外的CARV进行总结。
Respiratory viruses have been recognized as a significant cause of morbidity and mortality in patients with leukemia and those undergoing hematopoietic stem cell transplantation. The risk for lower respiratory tract infections and a fatal outcome appears to depend on the intrinsic virulence of the specific community-acquired respiratory virus as well as factors specific to the patient, the underlying disease, and its treatment. Community-acquired respiratory virus (CARV) infections have been recognized as a significant cause of morbidity and mortality in patients with leukemia and those undergoing hematopoietic stem cell transplantation (HSCT). Progression to lower respiratory tract infection with clinical and radiological signs of pneumonia and respiratory failure appears to depend on the intrinsic virulence of the specific CARV as well as factors specific to the patient, the underlying disease, and its treatment. To better define the current state of knowledge of CARVs in leukemia and HSCT patients, and to improve CARV diagnosis and management, a working group of the Fourth European Conference on Infections in Leukaemia (ECIL-4) 2011 reviewed the literature on CARVs, graded the available quality of evidence, and made recommendations according to the Infectious Diseases Society of America grading system. Owing to differences in screening, clinical presentation, and therapy for influenza and adenovirus, ECIL-4 recommendations are summarized for CARVs other than influenza and adenovirus.
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影响因子：
6.4
作者：
Cortez, KJ;Erdman, DD;Bennett, JE
通讯作者：
Bennett, JE
影响因子：
6.4
作者：
Campbell, Angela P.;Chien, Jason W.;Boeckh, Michael
通讯作者：
Boeckh, Michael
影响因子：
4.8
作者：
Hohenthal, U;Nikoskelainen, J;Kotilainen, P
通讯作者：
Kotilainen, P
影响因子：
39.2
作者：
Englund, JA;Boeckh, M;Corey, L
通讯作者：
Corey, L
影响因子：
5.9
作者：
Couch, Robert B.;Englund, Janet A.;Whimbey, Estella
通讯作者：
Whimbey, Estella