Emerging Exosomes and Exosomal MiRNAs in Spinal Cord Injury.
Emerging Exosomes and Exosomal MiRNAs in Spinal Cord Injury.
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DOI：
10.3389/fcell.2021.703989
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发表时间：
2021
影响因子：
5.5
通讯作者：
Chen L
中科院分区：
文献类型：
--
作者：
Feng J;Zhang Y;Zhu Z;Gu C;Waqas A;Chen L
急性脊髓损伤（SCI）是一种严重的脊髓创伤事件，具有相当高的发病率和死亡率。这种损伤会导致脊髓的短期和长期变化，并对患者的感觉、运动或自主功能产生严重影响。由于SCI病理过程复杂，目前临床尚无成功的治疗策略。外泌体是一种直径为 30-150 nm 的双层膜结构的细胞外囊泡 (EV)，最近被认为是细胞和组织之间通过转移蛋白质、脂质和核酸进行通讯的关键介质。进一步的研究证实，外泌体参与了多种疾病的病理生理过程，包括癌症、神经退行性疾病和心血管疾病，并可能对其治疗产生重大影响。作为生物活性物质的天然载体，外泌体已成为 SCI 的病理介质。在这篇综述文章中，我们批判性地讨论了外泌体作为细胞内介质的功能和 SCI 的潜在治疗方法，并对未来的研究提出了展望。
Acute spinal cord injury (SCI) is a serious traumatic event to the spinal cord with considerable morbidity and mortality. This injury leads to short- and long-term variations in the spinal cord, and can have a serious effect on the patient’s sensory, motor, or autonomic functions. Due to the complicated pathological process of SCI, there is currently no successful clinical treatment strategy. Exosomes, extracellular vesicles (EVs) with a double-layer membrane structure of 30–150 nm diameter, have recently been considered as critical mediators for communication between cells and tissues by transferring proteins, lipids, and nucleic acids. Further studies verified that exosomes participate in the pathophysiological process of several diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases, and could have a significant impact in their treatment. As natural carriers of biologically active cargos, exosomes have emerged as pathological mediators of SCI. In this review article, we critically discuss the functions of exosomes as intracellular mediators and potential treatments in SCI and provide an outlook on future research.
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