Long lasting recruitment of immune cells and altered epi-perineurial thickness in focal nerve inflammation induced by complete Freund's adjuvant.
Long lasting recruitment of immune cells and altered epi-perineurial thickness in focal nerve inflammation induced by complete Freund's adjuvant.
复制标题
DOI：
10.1016/j.jneuroim.2009.06.005
复制
发表时间：
2009-08-18
影响因子：
3.3
通讯作者：
Barbe MF
中科院分区：
文献类型：
--
作者：
Bove GM;Weissner W;Barbe MF
Immune-mediated nerve inflammation is involved in many painful states in humans, and causes axonal and behavioral changes in rats. While models of nerve inflammation have been characterized using electrophysiological and behavioral methods, the presence of immune cells has not been fully assessed. We inflamed rat sciatic nerves using complete Freund's adjuvant and quantified the presence of ED-1 macrophages and TCR-αβ T-cells for up to 12 weeks. We report that these immune cells are prominent extraneurally up to 12 weeks following the induction of inflammation. This observation does not easily correlate with inflammation-induced axonal mechanical sensitivity, which peaks within 1 week and is resolved after 8 weeks.
登录
查看更多内容
影响因子：
2.9
作者：
Amano, R;Hiruma, H;Shimizu, K
通讯作者：
Shimizu, K
影响因子：
4
作者：
Dilley, Andrew;Bove, Geoffrey M.
通讯作者：
Bove, Geoffrey M.
影响因子：
3.3
作者：
Armstrong, BD;Hu, Z;Waschek, JA
通讯作者：
Waschek, JA
影响因子：
3
作者：
RYDEVIK, B;BROWN, MD;NORDBORG, C
通讯作者：
NORDBORG, C
影响因子：
2.9
作者：
Todd, BA;Sedgwick, EM;Abbott, NJ
通讯作者：
Abbott, NJ