Increased Serum C3 and Decreased UA in Patients of Bipolar Disorder in Chinese Han Population.
Increased Serum C3 and Decreased UA in Patients of Bipolar Disorder in Chinese Han Population.
复制标题
中国汉族人群双相情感障碍患者血清C3升高和UA降低
DOI：
10.3389/fpsyt.2018.00381
复制
发表时间：
2018
影响因子：
4.7
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Yang X;Tao H;Xiao L;Li C;Tang Y;Liu Y
本研究旨在探讨双相情感障碍（BD）患者血清补体C3、C4、超敏C反应蛋白（hsCRP）和尿酸（UA）的变化及其临床意义。本研究采用病例对照研究的方法，选取中南大学湘雅二医院BD患者141例，湘雅二医院健康管理中心健康对照组151例。根据药物用途：将这些患者分为两个亚组：91例患者接受精神科药物治疗，50例患者未接受药物治疗;或根据情绪状态分为四个亚组：54例躁狂/轻躁狂期患者，30例抑郁期患者，52例情绪稳定期患者和5例混合期患者。检测所有受试者血清C3、C4、hsCRP和UA水平。BD患者血清补体C_3水平（0.9981 ± 0.1849 g/L）显著低于HC组（1.0637 ± 0.2186）g/L，尤以无药组和正常胸腺组为高（0.975 ± 0.153和0.983 ± 0.182 g/L），而血清UA水平显著高于对照组（P <0.01）。（354.6 ± 90.4 vs. 332.9 ± 88.7 μmol/L），尤其是药物治疗亚组和躁狂/轻躁狂亚组高尿酸血症的发生率（31.91%比17.88%，P < 0.05），BD组明显高于HC组（P < 0.05）。HC组血清C4、hsCRP水平与BD组及各亚组比较差异均无统计学意义。提示BD患者补体系统和嘌呤能系统可能存在紊乱，UA水平可能是BD躁狂期的一个潜在指标，C3可能是BD疗效评价的一个指标。
The aim of this study is to explore the changes and clinical significance of serum C3, C4, hypersensitive C-reactive protein (hsCRP) and uric acid (UA) in patients of bipolar disorder (BD). In this case-control study, we recruited 141 BD patients from The Second Xiangya Hospital, Central South University, and 151 age and gender matched healthy controls (HC) from the health management central of The Second Xiangya Hospital. These patients were divided into two subgroups based on medicines use: 91 patients were treated with psychiatric drugs and 50 patients were drugs free, or four subgroups based on mood states: 54 patients in manic/hypomanic phase, 30 patients in depressive phase, 52 patients in euthymic phase and 5 patients in mixed phase. Serum levels of C3, C4, hsCRP and UA were measured in all subjects. The serum C3 levels in BD patients (0.9981 ± 0.1849 g/L) were significantly lower than that in HC group (1.0637 ± 0.2186 g/L), especially the drugs free subgroup and the euthymic subgroup (0.975 ± 0.153 and 0.983 ± 0.182 g/L), while the serum UA levels were significantly higher (354.6 ± 90.4 vs. 332.9 ± 88.7 μmol/L), especially the drug-treated subgroup and manic/hypomanic subgroup (361.56 ± 93.20 and 376.70 ± 88.89 μmol/L), and rates of hyperuricaemia (31.91 vs. 17.88%) were significantly higher in BD patients than in HC group. The serum C4 and hsCRP levels in HC group showed no significant difference with BD patients in whole or those subgroups. These findings suggested that the complement and purinergic systems of BD patients might be disrupted, the UA levels could be a potential marker in manic phase and the C3 might be the marker of therapeutic evaluation of BD patients.
登录
查看更多内容
影响因子：
64.3
作者：
Fernandes, Brisa S.;Steiner, Johann;Berk, Michael
通讯作者：
Berk, Michael
情绪障碍的嘌呤能系统功能障碍：开发改进的治疗剂的关键目标。
DOI：
10.1016/j.pnpbp.2014.10.016
发表时间：
2015-03-03
影响因子：
5.6
作者：
Ortiz, Robin;Ulrich, Henning;Zarate, Carlos A., Jr.;Machado-Vieira, Rodrigo
通讯作者：
Machado-Vieira, Rodrigo
DOI：
10.3233/jad-2010-1330
发表时间：
2010
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Bowman GL;Shannon J;Frei B;Kaye JA;Quinn JF
通讯作者：
Quinn JF
影响因子：
3.2
作者：
Chung, Kuo-Hsuan;Huang, Shou-Hung;Tsai, Shang-Ying
通讯作者：
Tsai, Shang-Ying
DOI：
10.4088/jcp.v69n0806
发表时间：
2008-08
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
Machado-Vieira R;Soares JC;Lara DR;Luckenbaugh DA;Busnello JV;Marca G;Cunha A;Souza DO;Zarate CA Jr;Kapczinski F
通讯作者：
Kapczinski F