Opioid Use Disorder and COVID-19: Biological Plausibility for Worsened Outcomes.
Opioid Use Disorder and COVID-19: Biological Plausibility for Worsened Outcomes.
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DOI：
10.1080/10826084.2020.1791184
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发表时间：
2020
影响因子：
2
通讯作者：
Manini AF
中科院分区：
文献类型：
--
作者：
Schimmel J;Manini AF
有人警告说，COVID-19可能对某些物质使用障碍人群，特别是阿片类药物使用障碍人群产生不成比例的影响，但警告主要集中在服务可得性减少等社会风险上。这篇评论强调了感染COVID-19的OUD患者可能出现预后恶化的三种似是而非的生物学机制。阿片类药物相关的呼吸抑制可能会增加COVID-19病毒性肺炎低氧血症的风险。复杂的阿片免疫调节可能影响宿主对COVID-19的反应，但其作用方向和临床意义尚不清楚。药物-药物相互作用可能会影响同时服用OUD和COVID-19药物的OUD患者，特别是由于心脏不良反应。对于感染COVID-19的OUD患者可能出现的预后恶化，存在合理的生物学机制；这些机制需要进一步研究，并应在OUD患者中考虑。
Alarms have been raised that COVID-19 may disproportionately affect certain populations with substance use disorders, particularly Opioid Use Disorder (OUD), however warnings have largely focused on social risks such as reduced availability of services. This commentary highlights three plausible biological mechanisms for potentially worsened outcomes in patients with OUD who contract COVID-19. Opioid-related respiratory depression may amplify risks of hypoxemia from COVID-19 viral pneumonia. Complex opioid immune modulation may impact host response to COVID-19, though the effect direction and clinical significance are unclear. Drug-drug interactions may affect individuals with OUD who are co-administered medications for OUD and medications for COVID-19, particularly due to cardiac adverse effects. There are plausible biological mechanisms for potentially worsened outcomes in patients with OUD who contract COVID-19; these mechanisms require further study, and should be considered in individuals with OUD.
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影响因子：
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作者：
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期刊：
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