Bile Acid Signaling in Neurodegenerative and Neurological Disorders.
Bile Acid Signaling in Neurodegenerative and Neurological Disorders.
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DOI：
10.3390/ijms21175982
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发表时间：
2020-08-20
影响因子：
5.6
通讯作者：
DeMorrow S
中科院分区：
文献类型：
--
作者：
Grant SM;DeMorrow S
胆汁酸通常被认为是脂类的消化剂。胆汁酸在正常生理条件下以及肝脏和胆汁淤积性疾病期间在胃肠道中的机制已得到充分研究。胆汁酸还可作为信号分子的配体，如核受体法尼醇X受体和膜结合受体、武田G蛋白偶联胆汁酸受体和鞘氨醇-1-磷酸受体2。最近的研究表明，胆汁酸信号也可能在中枢神经系统中发挥普遍作用。一些胆汁酸，如牛磺熊去氧胆酸和熊去氧胆酸，在许多神经系统疾病的实验动物模型和临床研究中显示出神经保护潜力。胆汁酸代谢的改变已被发现作为预后工具的潜在生物标志物以及多种神经系统疾病中各种胆汁酸受体的表达。本文综述了近年来胆汁酸介导的治疗和信号转导及其在神经退行性疾病和神经系统疾病中的作用。
Bile acids are commonly known as digestive agents for lipids. The mechanisms of bile acids in the gastrointestinal track during normal physiological conditions as well as hepatic and cholestatic diseases have been well studied. Bile acids additionally serve as ligands for signaling molecules such as nuclear receptor Farnesoid X receptor and membrane-bound receptors, Takeda G-protein-coupled bile acid receptor and sphingosine-1-phosphate receptor 2. Recent studies have shown that bile acid signaling may also have a prevalent role in the central nervous system. Some bile acids, such as tauroursodeoxycholic acid and ursodeoxycholic acid, have shown neuroprotective potential in experimental animal models and clinical studies of many neurological conditions. Alterations in bile acid metabolism have been discovered as potential biomarkers for prognosis tools as well as the expression of various bile acid receptors in multiple neurological ailments. This review explores the findings of recent studies highlighting bile acid-mediated therapies and bile acid-mediated signaling and the roles they play in neurodegenerative and neurological diseases.
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影响因子：
--
作者：
Dawson, Paul A
通讯作者：
Dawson, Paul A
影响因子：
14
作者：
通讯作者：
--
影响因子：
5.1
作者：
Abdelkader, Noha F.;Safar, Marwa M.;Salem, Hesham A.
通讯作者：
Salem, Hesham A.
Ursodoxycholic酸改善了线粒体功能，并在患有零星或家族性阿尔茨海默氏病的患者的成纤维细胞中重新分布DRP1。
影响因子：
5.6
作者：
Bell SM;Barnes K;Clemmens H;Al-Rafiah AR;Al-Ofi EA;Leech V;Bandmann O;Shaw PJ;Blackburn DJ;Ferraiuolo L;Mortiboys H
通讯作者：
Mortiboys H
影响因子：
5.8
作者：
Chiang JY
通讯作者：
Chiang JY