Human cytomegalovirus neutralizing antibody response in Japanese children with bone marrow transplantation.
Human cytomegalovirus neutralizing antibody response in Japanese children with bone marrow transplantation.
复制标题
日本骨髓移植儿童的人巨细胞病毒中和抗体反应。
DOI：
--
复制
发表时间：
1994
影响因子：
2.2
通讯作者：
T. Konno
中科院分区：
文献类型：
--
作者：
Y. Ohizumi;H. Suzuki;Y. Numazaki;M. Imaizumi;Y. Koisumi;K. Tada;M. Minegishi;S. Tsuchiya;T. Konno
32例儿童骨髓移植(BMT)患儿于移植前1周至术后4个月静脉注射丙种球蛋白(IVIG)，其中抗人巨细胞病毒(HCMV)中和抗体(NT)滴度为200 mg/kg/周。比较每个患者骨髓移植前的NT抗体滴度和骨髓移植后进行的系列检测的最高水平。根据抗体反应分为三组：原发HCMV感染组为I组，内源性再感染或再感染组为II组，不明原因病例组为III组。32例患者中有2例(6.3%)存在骨髓移植相关的原发HCMV感染，但无任何临床症状。所有其他30名患者的临床参数也没有显著变化，无论他们是否将病毒排入尿液，或显示为抗体增强。从群体变异中得出结论，抗体反应确实是由于骨髓移植的植入，而不是静脉注射免疫球蛋白治疗的直接效果。我们的结果进一步表明，用HCMV抗体被动免疫不能预防感染，但对症状性疾病有一定的保护作用。
Thirty-two children with bone marrow transplantation (BMT) received intravenous injections of gammaglobulin (IVIG) with a high titer of neutralizing (NT) antibody against human cytomegalovirus (HCMV) (200 mg/kg/week) from 1 week before to 4 months after transplantation. NT antibody titers before BMT and the highest levels in serial determinations conducted after BMT were compared for each patient. They were classified into three groups according to the antibody response: primary HCMV infection as group I, endogenous reactivation or external reinfection as group II, and indeterminable cases as group III. Two (6.3%) out of 32 patients examined had BMT-associated primary HCMV infections, but did not show any clinical symptoms. Significant changes in clinical parameters were also lacking in all the other 30 patients, independent of whether they shed viruses into the urine, or demonstrated on antibody boost. It was concluded from the group variation that the antibody response was indeed due to the engraftment of BMT, rather than to a direct effect of treatment with IVIG. Our results further indicate that passive immunization with HCMV antibody does not prevent infection, but confers some protection against symptomatic disease.
BMT 后预防 CMV 感染。
影响因子：
4.8
作者：
Zaia,JA;Schmidt,GM
通讯作者：
Schmidt,GM
骨髓移植后巨细胞病毒感染：与急性移植物抗宿主病的关联。
影响因子：
20.3
作者：
Miller,W;Flynn,P;McCullough,J;BalfourJr,HH;Goldman,A;Haake,R;McGlave,P;Ramsay,N;Kersey,J
通讯作者：
Kersey,J
影响因子：
6.4
作者：
RASMUSSEN, L;MATKIN, C;MERIGAN, TC
通讯作者：
MERIGAN, TC