Local learning rules: predicted influence of dendritic location on synaptic modification in spike-timing-dependent plasticity
Local learning rules: predicted influence of dendritic location on synaptic modification in spike-timing-dependent plasticity
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局部学习规则：树突位置对尖峰时间依赖性可塑性突触修饰的预测影响
DOI：
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发表时间：
2005
影响因子：
1.9
通讯作者：
F. Wörgötter
中科院分区：
文献类型：
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作者：
A. Saudargienė;B. Porr;F. Wörgötter
摘要：最近的间接实验证据表明，突触可塑性沿着神经元的树突发生变化。在这里，我们提出了一个突触可塑性规则，这是由突触前和突触后信号的属性控制。使用记录的膜痕迹的反向传播和树突棘波，我们表明，LTP和LTD将具体取决于在一个给定的树突状网站的突触后去极化的形状。我们发现，不对称的尖峰定时依赖可塑性（STDP）可以取代时间上对称的可塑性在生理相关的时间窗口内，如果突触后去极化上升浅。突触前的规则取决于NMDA通道的特性，该模型预测，增加镁2+将衰减STDP曲线，而不改变其形状。此外，该模型表明，LTD的轮廓应该是由突触后信号，而LTP主要取决于突触前信号的形状。
Abstract.Recent indirect experimental evidence suggests that synaptic plasticity changes along the dendrites of a neuron. Here we present a synaptic plasticity rule which is controlled by the properties of the pre- and postsynaptic signals. Using recorded membrane traces of back-propagating and dendritic spikes we demonstrate that LTP and LTD will depend specifically on the shape of the postsynaptic depolarization at a given dendritic site. We find that asymmetrical spike-timing-dependent plasticity (STDP) can be replaced by temporally symmetrical plasticity within physiologically relevant time windows if the postsynaptic depolarization rises shallow. Presynaptically the rule depends on the NMDA channel characteristic, and the model predicts that an increase in Mg2+ will attenuate the STDP curve without changing its shape. Furthermore, the model suggests that the profile of LTD should be governed by the postsynaptic signal while that of LTP mainly depends on the presynaptic signal shape.
影响因子：
2.5
作者：
Chen, HX;Otmakhov, N;Lisman, J
通讯作者：
Lisman, J
影响因子：
2.5
作者：
Yang, SN;Tang, YG;Zucker, RS
通讯作者：
Zucker, RS
影响因子：
3.7
作者：
Abbott, LF;Blum, KI
通讯作者：
Blum, KI