An increase in tobacco craving is associated with enhanced medial prefrontal cortex network coupling.
An increase in tobacco craving is associated with enhanced medial prefrontal cortex network coupling.
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DOI：
10.1371/journal.pone.0088228
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Lukas SE
中科院分区：
文献类型：
--
作者：
Janes AC;Farmer S;Frederick Bd;Nickerson LD;Lukas SE
渴望是药物依赖的一个关键方面，被认为是促使继续使用药物的原因。许多大脑区域与渴望有关，这表明渴望是由分布式大脑网络介导的。在尼古丁依赖的参与者中，使用静息状态功能磁成像（fMRI）评估了主观渴望的增加是否与大脑区域之间增强的相互作用有关。我们专注于与渴求相关的变化，在眶和内侧前额叶皮层（OMPFC）网络，其中还包括膝下前扣带皮层（sgACC）延伸到腹侧纹状体。OMPFC网络中的大脑区域不仅与成瘾和奖励有关，而且由于它们丰富的解剖学互连，可能是与渴望相关的大脑区域整合的场所。主观渴望和静息状态功能磁共振成像评估两次，扫描之间有0.1小时的延迟。相对于扫描开始时，吸烟欲望在结束时显著增加。增强的渴望与OMPFC网络和其他皮层、边缘系统、纹状体和内脏脑区域之间的耦合增强有关，这些区域在解剖学上都与OMPFC相互连接，并与成瘾和渴望有关。这是第一次证实渴望的增加与增强的大脑区域相互作用有关，这可能在渴望的体验中发挥作用。
Craving is a key aspect of drug dependence that is thought to motivate continued drug use. Numerous brain regions have been associated with craving, suggesting that craving is mediated by a distributed brain network. Whether an increase in subjective craving is associated with enhanced interactions among brain regions was evaluated using resting state functional magnetic imaging (fMRI) in nicotine dependent participants. We focused on craving-related changes in the orbital and medial prefrontal cortex (OMPFC) network, which also included the subgenual anterior cingulate cortex (sgACC) extending into the ventral striatum. Brain regions in the OMPFC network are not only implicated in addiction and reward, but, due to their rich anatomic interconnections, may serve as the site of integration across craving-related brain regions. Subjective craving and resting state fMRI were evaluated twice with an ∼1 hour delay between the scans. Cigarette craving was significantly increased at the end, relative to the beginning of the scan session. Enhanced craving was associated with heightened coupling between the OMPFC network and other cortical, limbic, striatal, and visceromotor brain regions that are both anatomically interconnected with the OMPFC, and have been implicated in addiction and craving. This is the first demonstration confirming that an increase in craving is associated with enhanced brain region interactions, which may play a role in the experience of craving.
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DOI：
10.1523/jneurosci.1914-12.2012
发表时间：
2012-08-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fanous S;Goldart EM;Theberge FR;Bossert JM;Shaham Y;Hope BT
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Hope BT
影响因子：
3.4
作者：
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影响因子：
7.6
作者：
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Heidbreder, CA
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
2.5
作者：
Bray, Signe;Shimojo, Shinsuke;O'Doherty, John P.
通讯作者：
O'Doherty, John P.