High rate of dyspareunia and probable vulvodynia in Ehlers-Danlos syndromes and hypermobility spectrum disorders: An online survey.
High rate of dyspareunia and probable vulvodynia in Ehlers-Danlos syndromes and hypermobility spectrum disorders: An online survey.
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DOI：
10.1002/ajmg.c.31939
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Schlaeger JM
中科院分区：
文献类型：
--
作者：
Glayzer JE;McFarlin BL;Castori M;Suarez ML;Meinel MC;Kobak WH;Steffen AD;Schlaeger JM
外阴疼痛是一种使人衰弱的外阴疼痛，伴有性交困难（性交疼痛）。Ehlers-Danlos综合征（EDS）和高动性谱系障碍（HSD）可能是外阴痛的诱发因素，因为在这些疾病中性交困难的发生率很高。我们对患有EDS或HSD的女性进行了一项在线调查，以评估性交困难的发生率并估计外阴痛的发生率，报告EDS或HSD和外阴痛常见的共病情况的发生率，并检查EDS或HSD女性中导致性交困难的情况的发生率。通过社交媒体招募的患有EDS或HSD的女性（N = 1，146）年龄为38.2 ± 11.5岁，主要是白色（94.4%），居住在美国（78.5%）。63.7%的参与者报告性交困难，50%的外阴痛筛查阳性。EDS或HSD和外阴痛的共病率为：肠易激综合征，6.5%;纤维肌痛，40.0%;颞下颌关节功能障碍，56.4%;偏头痛，6.7%;间质性膀胱炎，1.7%;肥大细胞活化综合征，10.2%。报告性交困难的参与者还报告了卵巢囊肿、肌瘤或腹部或盆腔瘢痕（47.5%）;子宫内膜异位症（26.5%）;生殖器撕裂伤（19.3%）。患有EDS或HSD的女性外阴痛的发生率（50.0%）可能高于美国人群中的女性（8%），应评估性交困难和外阴痛。
Vulvodynia is debilitating vulvar pain accompanied by dyspareunia (pain with sexual intercourse). Ehlers–Danlos syndromes (EDS) and hypermobility spectrum disorders (HSD) may represent a predisposing factor for vulvodynia given a high rate of dyspareunia in these conditions. We conducted an online survey of women with EDS or HSD to assess rates of dyspareunia and estimate rates of vulvodynia, report rates of comorbid conditions common to EDS or HSD and vulvodynia, and examine rates of conditions contributing to dyspareunia in women with EDS or HSD. Women with EDS or HSD (N = 1,146) recruited via social media were 38.2 ± 11.5 years old, primarily White (94.4%), and resided in the United States (78.5%). 63.7% of participants reported dyspareunia and 50% screened positive for vulvodynia. The rate of comorbid conditions common to EDS or HSD and vulvodynia were: irritable bowel syndrome, 6.5%; fibromyalgia, 40.0%; temporomandibular joint dysfunction, 56.4%; migraine, 6.7%; interstitial cystitis, 1.7%; and mast cell activation syndrome, 10.2%. Participants reporting dyspareunia also reported ovarian cysts, fibroids, or abdominal or pelvic scars, 47.5%; endometriosis, 26.5%; and genital lacerations, 19.3%. Women with EDS or HSD may have a higher rate of vulvodynia (50.0%) than women in the U.S. population at large (8%) and should be assessed for dyspareunia and vulvodynia.
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发表时间：
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