Effects of methylphenidate on processing negativities in patients with attention-deficit hyperactivity disorder.
Effects of methylphenidate on processing negativities in patients with attention-deficit hyperactivity disorder.
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哌醋甲酯对注意力缺陷多动障碍患者处理消极情绪的影响。
DOI：
10.1111/j.1469-8986.1990.tb00391.x
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发表时间：
1990
期刊：
影响因子：
3.7
通讯作者：
Loeb,S
中科院分区：
文献类型：
--
作者：
Klorman,R;Brumaghim,JT;Salzman,LF;Strauss,J;Borgstedt,AD;McBride,MC;Loeb,S
这项研究比较了哌甲酯对注意缺陷多动障碍（ADHD）患者的影响，这些患者有和没有攻击性/不依从性特征，在一项由随机排序的一系列大声（频繁）音调，柔和（罕见）音调，明亮（频繁）灯光和昏暗（罕见）灯光组成的古怪测试中。在交替的条件下，受试者被要求对罕见的音调或罕见的灯光做出反应。这些任务在无药物基线期和哌醋甲酯（0.3 mg/Kg b.i.d.）和安慰剂（乳糖b.i.d.）。与安慰剂相比，哌醋甲酯导致对两种模式的目标的反应的更高准确性和速度。当目标是稀有音调而不是稀有光线时，N1对听觉非目标的振幅更大，并且这种与注意力相关的效应会被哌甲酯增强。相同的差异幅度增强兴奋剂治疗被发现的早期面积测量的差异ERPs。相比之下，对于N1视觉非目标的选择性注意的效果（较大的幅度时，目标是一个罕见的光与罕见的音调）是不显着的，不受兴奋剂药物的影响。所有这些研究结果在三个ADHD亚组中具有可比性，这一结果证明了刺激对信息处理的普遍影响。
This study compared the impact of methylphenidate on patients with Attention‐deficit Hyperactivity Disorder (ADHD) with and without aggressive/noncompliant features in an oddball test consisting of a randomly ordered series of loud (frequent) tones, soft (rare) tones, bright (frequent) lights, and dim (rare) lights. In alternate conditions, subjects were required to respond to either the rare tones or the rare lights. These tasks were administered in a drug‐free baseline session and after a counterbalanced treatment of 14 days each of methylphenidate (0.3 mg/Kg b.i.d.) and placebo (lactose b.i.d.). In comparison with placebo, methylphenidate resulted in greater accuracy and speed of reactions to targets of both modalities. The amplitude of N1 to auditory nontargets was larger when the target was a rare tone as opposed to a rare light, and this attention‐related effect was increased by methylphenidate. The same differential amplitude enhancement by stimulant treatment was found for an early area measure of difference ERPs. In contrast, for N1 to visual nontargets the effect of selective attention (larger amplitude when the target was a rare light vs. a rare tone) was not significant and was not affected by stimulant medication. All these findings were comparable for the three ADHD subgroups, a result attesting to the generality of stimulant effects on information processing.
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选择性注意力和皮质对视觉和听觉刺激的诱发反应
影响因子：
56.9
作者：
P. Spong;M. Haider;D. Lindsley
通讯作者：
D. Lindsley
哌甲酯对多动儿童母子互动的影响。
影响因子：
--
作者：
R. Barkley;C. Cunningham
通讯作者：
C. Cunningham
哌醋甲酯对年轻人在警惕性和配对联想学习测试中的表现和事件相关电位的影响。
影响因子：
3.7
作者：
J. Strauss;J. Lewis;R. Klorman;L. Péloquin;R. Perlmutter;L. Salzman
通讯作者：
L. Salzman
影响因子：
--
作者：
J. Rapoport;M. Buchsbaum;H. Weingartner;T. Zahn;C. Ludlow;E. Mikkelsen
通讯作者：
E. Mikkelsen
DOI：
10.1016/0013-4694(80)90389-2
发表时间：
1980-01-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
HARTER, MR;GUIDO, W
通讯作者：
GUIDO, W