The role of hypothalamic estrogen receptors in metabolic regulation.
The role of hypothalamic estrogen receptors in metabolic regulation.
复制标题
DOI：
10.1016/j.yfrne.2014.05.002
复制
发表时间：
2014-10
影响因子：
7.4
通讯作者：
Clegg, Deborah J.
中科院分区：
文献类型：
--
作者：
Frank, Aaron;Brown, Lynda M.;Clegg, Deborah J.
关键词：
Estrogens regulate key features of metabolism, including food intake, body weight, energy expenditure, insulin sensitivity, leptin sensitivity, and body fat distribution. There are two ”classical“ estrogen receptors (ERs): estrogen receptor alpha (ERS1) and estrogen receptor beta (ERS2). Human and murine data indicate ERS1 contributes to metabolic regulation more so than ESR2. For example, there are human inactivating mutations of ERS1 which recapitulate aspects of the metabolic syndrome in both men and women. Much of our understanding of the metabolic roles of ERS1 was initially uncovered in estrogen receptor α-null mice (ERS1−/−); these mice display aspects of the metabolic syndrome, including increased body weight, increased visceral fat deposition and dysregulated glucose intolerance. Recent data further implicate ERS1 in specific tissues and neuronal populations as being critical for regulating food intake, energy expenditure, body fat distribution and adipose tissue function. This review will focus predominantly on the role of hypothalamic ERs and their critical role in regulating all aspects of energy homeostasis and metabolism.
登录
查看更多内容
影响因子：
4.1
作者：
Bennett, PA;Lindell, K;Robinson, ICAF
通讯作者：
Robinson, ICAF
影响因子：
7.7
作者：
Baskin, DG;Breininger, JF;Schwartz, MW
通讯作者：
Schwartz, MW
影响因子：
4.8
作者：
BONAVERA, JJ;DUBE, MG;KALRA, SP
通讯作者：
KALRA, SP
影响因子：
2.9
作者：
BUTERA, PC;BEIKIRCH, RJ
通讯作者：
BEIKIRCH, RJ
影响因子：
64.5
作者：
Chen, H;Charlat, O;Morgenstern, JP
通讯作者：
Morgenstern, JP