Ethnic differences in breast cancer incidence in England are due to differences in known risk factors for the disease: prospective study.
Ethnic differences in breast cancer incidence in England are due to differences in known risk factors for the disease: prospective study.
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英国乳腺癌发病率的种族差异是由于已知的该疾病危险因素的差异造成的：前瞻性研究。
DOI：
10.1038/bjc.2013.632
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发表时间：
2014-01-07
影响因子：
8.8
通讯作者：
Moser, K. A.
中科院分区：
文献类型：
--
作者：
Gathani, T.;Ali, R.;Balkwill, A.;Green, J.;Reeves, G.;Beral, V.;Moser, K. A.
在英国，南亚和黑人妇女的乳腺癌发病率低于白人妇女，但这在多大程度上是由已知的危险因素造成的尚不清楚。在一项大型前瞻性研究中，我们按种族描述乳腺癌发病率，在调整已知疾病危险因素之前和之后。1996年至2001年期间，百万妇女研究项目招募了一些妇女，以获得有关已知影响乳腺癌风险的生殖和生活方式因素的信息。种族是根据研究问卷和住院数据确定的。采用Cox回归模型计算南亚人和黑人与白人相比发生乳腺癌的校正相对危险度（RR）。分析对象包括英国5877名南亚女性、4919名黑人女性和1038144名白人女性。研究发现，在乳腺癌的9个危险因素中，8个因素的患病率因种族而有很大差异（每个因素的P<0.001），因此南亚和黑人妇女的患病风险低于白人妇女。在12.2年的随访中，217名南亚人、180名黑人和45191名白人发生了乳腺癌。正如预期的那样，当分析仅根据年龄和居住地区进行调整时，南亚人（RR=0.82, 95% CI 0.72-0.94）和黑人（RR=0.85, 0.73-0.98）的乳腺癌发病率低于白人。然而，在对已知的疾病危险因素进行额外调整后，南亚人（0.95,0.83-1.09）和黑人（0.91,0.78-1.05）的乳腺癌发病率与白人相似。在英国，南亚和黑人妇女的乳腺癌发病率低于白人妇女，但这在很大程度上（如果不是全部的话）是因为已知的乳腺癌危险因素的差异。
In the United Kingdom, breast cancer incidence is lower in South Asian and Black women than in White women, but the extent to which this is due to known risk factors is unknown. In a large prospective study, we describe breast cancer incidence by ethnicity, before and after adjustment for known risk factors for the disease. Women were recruited into the Million Women Study in 1996–2001, when information on reproductive and lifestyle factors known to influence the risk of breast cancer was obtained. Ethnicity was determined from study questionnaires and hospital admission data. Cox regression models were used to calculate adjusted relative risks (RR) for incident breast cancer in South Asians and Blacks compared with Whites. Analyses included 5877 South Asian, 4919 Black, and 1 038 144 White women in England. The prevalence of 8 out of the 9 risk factors for breast cancer examined, differed substantially by ethnicity (P<0.001 for each), such that South Asian and Black women were at a lower risk of the disease than White women. During 12.2 years of follow-up incident breast cancer occurred in 217 South Asians, 180 Blacks, and 45 191 Whites. As expected, breast cancer incidence was lower in South Asians (RR=0.82, 95% CI 0.72–0.94) and Blacks (RR=0.85, 0.73–0.98) than in Whites when the analyses were adjusted only for age and region of residence. However, after additional adjustment for the known risk factors for the disease, breast cancer incidence was similar to that of Whites, both in South Asians (0.95, 0.83–1.09) and in Blacks (0.91, 0.78–1.05). South Asian and Black women in England have lower incidence rates of breast cancer than White women, but this is largely, if not wholly, because of differences in known risk factors for the disease.
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影响因子：
51.1
作者：
Green, Jane;Cairns, Benjamin J.;Casabonne, Delphine;Wright, F. Lucy;Reeves, Gillian;Beral, Valerie
通讯作者：
Beral, Valerie
影响因子：
6.3
作者：
Farooq, S;Coleman, MP
通讯作者：
Coleman, MP
影响因子：
8.8
作者：
Beral, V;Hamajima, N;Hirose, K;Rohan, T;Calle, EE;Heath, CW;Coates, RJ;Liff, JM;Talamini, R;Chantarakul, N;Koetsawang, S;Rachawat, D;Morabia, A;Schuman, L;Stewart, W;Szklo, M;Bain, C;Schofield, F;Siskind, V;Band, P;Coldman, AJ;Gallagher, RP;Hislop, TG;Yang, P;Kolonel, LM;Nomura, AMY;Hu, J;Johnson, KC;Mao, Y;De Sanjose, S;Lee, N;Marchbanks, P;Ory, HW;Peterson, HB;Wilson, HG;Wingo, PA;Ebeling, K;Kunde, D;Nishan, P;Hopper, JL;Colditz, G;Gajalakshmi, V;Martin, N;Pardthaisong, T;Solpisornkosol, S;Theetranont, C;Boosiri, B;Chutivongse, S;Jimakorn, P;Virutamasen, P;Wongsrichanalai, C;Ewertz, M;Adami, HO;Bergkvist, L;Magnusson, C;Persson, I;Chang-Claude, J;Paul, C;Skegg, DCG;Spears, GFS;Boyle, P;Evstifeeva, T;Daling, JR;Hutchinson, WB;Malone, K;Noonan, EA;Stanford, JL;Thomas, DB;Weiss, NS;White, E;Andrieu, N;Brêmond, A;Clavel, F;Gairard, B;Lansac, J;Piana, L;Renaud, R;Izquierdo, A;Viladiu, P;Cuevas, HR;Ontiveros, P;Palet, A;Salazar, SB;Arsitizabal, N;Cuadros, A;Tryggvadottir, L;Tulinius, H;Bachelot, A;Lê, MG;Peto, J;Franceschi, S;Lubin, F;Modan, B;Ron, E;Wax, Y;Friedman, GD;Hiatt, RA;Levi, F;Bishop, T;Kosmelj, K;Primic-Zakelj, M;Ravnihar, B;Stare, J;Beeson, WL;Fraser, G;Bulbrook, RD;Cuzick, J;Duffy, SW;Fentiman, IS;Hayward, JL;Wang, DY;McMichael, AJ;McPherson, K;Hanson, RL;Leske, MC;Mahoney, MC;Nasca, PC;Varma, AO;Weinstein, AL;Moller, TR;Olsson, H;Ranstam, J;Goldbohm, RA;van den Brandt, PA;Apelo, RA;Baens, J;de la Cruz, JR;Javier, B;Lacaya, LB;Ngelangel, CA;La Vecchia, C;Negri, E;Marubini, E;Ferraroni, M;Gerber, M;Richardson, S;Segala, C;Gatei, D;Kenya, P;Kungu, A;Mati, JG;Brinton, LA;Hoover, R;Schairer, C;Spirtas, R;Lee, HP;Rookus, MA;van Leeuwen, FE;Schoenberg, JA;McCredie, M;Gammon, MD;Clarke, EA;Jones, L;Neil, A;Vessey, M;Yeates, D;Appleby, P;Banks, E;Bull, D;Crossley, B;Goodill, A;Green, J;Hermon, C;Key, T;Langston, N;Lewis, C;Reeves, G;Collins, R;Doll, R;Peto, R;Mabuchi, K;Preston, D;Hannaford, P;Kay, C;Rosero-Bixby, L;Gao, YT;Jin, F;Yuan, JM;Wei, HY;Yun, T;Zhiheng, C;Berry, G;Cooper Booth, J;Jelihovsky, T;MacLennan, R;Shearman, R;Wang, QS;Baines, CJ;Miller, AB;Wall, C;Lund, E;Stalsberg, H;Shu, XO;Zheng, W;Katsouyanni, K;Trichopoulou, A;Trichopoulos, D;Dabancens, A;Martinez, L;Molina, R;Salas, O;Alexander, XE;Anderson, K;Folsom, AR;Hulka, BS;Bernstein, L;Enger, S;Haile, RW;Paganini-Hill, A;Pike, MC;Ross, RK;Ursin, G;Yu, MC;Longnecker, MP;Newcomb, P;Bergkvist, L;Kalache, A;Farley, TMM;Holck, S;Meirik, O
通讯作者：
Meirik, O
影响因子：
105.7
作者：
Hawkins, Summer Sherburne;Lamb, Kate;Law, Catherine
通讯作者：
Law, Catherine
DOI：
10.1016/s1470-2045(12)70425-4
发表时间：
2012-11
期刊：
The Lancet. Oncology
影响因子：
--
作者：
Collaborative Group on Hormonal Factors in Breast Cancer
通讯作者：
Collaborative Group on Hormonal Factors in Breast Cancer