Magnetic resonance elastography of the brain using multishot spiral readouts with self-navigated motion correction.
Magnetic resonance elastography of the brain using multishot spiral readouts with self-navigated motion correction.
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DOI：
10.1002/mrm.24473
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发表时间：
2013-08
影响因子：
3.3
通讯作者：
Georgiadis, John G.
中科院分区：
文献类型：
--
作者：
Johnson, Curtis L.;McGarry, Matthew D. J.;Van Houten, Elijah E. W.;Weaver, John B.;Paulsen, Keith D.;Sutton, Bradley P.;Georgiadis, John G.
MRE已被引入临床实践中作为一个可能的替代机械触诊，但其应用研究人脑在体内一直受到限制的低空间分辨率和复杂的逆问题与生物力学性能估计。在这里，我们报告显着改善大脑磁共振成像数据采集报告图像具有高空间分辨率和信噪比量化的八面体剪切应变度量。具体来说，我们已经开发了一个序列的大脑磁共振成像的基础上多拍，变密度螺旋成像和三维位移采集，并实施了任何由此产生的相位误差的校正方案。采用瑞利阻尼脑组织力学模型来表示脑实质，并通过基于有限元的迭代反演算法进行集成。多分辨率体模研究表明，需要获得高分辨率的MRE数据时，估计局灶性机械性能。对三名健康志愿者的测量表明灰色和白色物质的分辨率令人满意，机械不均匀性与白色物质的组织结构相一致。总之，这些进步使得MRE扫描能够产生对体内脑组织机械特性的高保真度、空间分辨的估计，从而改进仅报告体积平均刚度值的较低分辨率MRE脑部研究。
MRE has been introduced in clinical practice as a possible surrogate for mechanical palpation, but its application to study the human brain in vivo has been limited by low spatial resolution and the complexity of the inverse problem associated with biomechanical property estimation. Here, we report significant improvements in brain MRE data acquisition by reporting images with high spatial resolution and signal-to-noise ratio as quantified by octahedral shear strain metrics. Specifically, we have developed a sequence for brain MRE based on multi-shot, variable-density spiral imaging and three-dimensional displacement acquisition, and implemented a correction scheme for any resulting phase errors. A Rayleigh damped model of brain tissue mechanics was adopted to represent the parenchyma, and was integrated via a finite element-based iterative inversion algorithm. A multi-resolution phantom study demonstrates the need for obtaining high-resolution MRE data when estimating focal mechanical properties. Measurements on three healthy volunteers demonstrate satisfactory resolution of grey and white matter, and mechanical heterogeneities correspond well with white matter histoarchitecture. Together, these advances enable MRE scans that result in high-fidelity, spatially-resolved estimates of in vivo brain tissue mechanical properties, improving upon lower resolution MRE brain studies which only report volume averaged stiffness values.
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通过磁共振弹性成像确定阿尔茨海默氏病的大脑硬度降低。
影响因子：
4.4
作者：
Murphy, Matthew C.;Huston, John, III;Jack, Clifford R., Jr.;Glaser, Kevin J.;Manduca, Armando;Felmlee, Joel P.;Ehman, Richard L.
通讯作者：
Ehman, Richard L.
影响因子：
2.4
作者：
Kaster, T.;Sack, I.;Samani, A.
通讯作者：
Samani, A.
影响因子：
3.5
作者：
McGarry MD;Van Houten EE;Perriñez PR;Pattison AJ;Weaver JB;Paulsen KD
通讯作者：
Paulsen KD
影响因子：
56.9
作者：
MUTHUPILLAI, R;LOMAS, DJ;EHMAN, RL
通讯作者：
EHMAN, RL
影响因子：
2.8
作者：
Freimann, Florian Baptist;Streitberger, Kaspar-Josche;Sack, Ingolf
通讯作者：
Sack, Ingolf