Qinggan Huoxue Recipe attenuates Alcoholic Liver Disease by suppressing PI3K/AKT signaling pathway based on network pharmacology.
Qinggan Huoxue Recipe attenuates Alcoholic Liver Disease by suppressing PI3K/AKT signaling pathway based on network pharmacology.
复制标题
基于网络药理学的清肝活血方通过抑制PI3K/AKT信号通路减轻酒精性肝病
DOI：
10.7150/ijms.80329
复制
发表时间：
2023
影响因子：
3.6
通讯作者：
Wu T
中科院分区：
文献类型：
--
作者：
Wang J;Lu Y;Zhang C;Tian S;Xiang H;Ding P;Chen J;Ji G;Wu T
清肝活血方是在小柴胡汤的基础上发展而来的。许多实验研究证实，清肝活血方能显著缓解酒精性肝病（ALD）的症状，但其详细机制尚不清楚。利用中药网络药理分析系统数据库和动物实验，从中药复方中筛选出180个潜在化学成分和618个潜在作用靶点，与ALD共有133条信号通路。通过动物实验发现，清肝活血方能降低ALD小鼠肝脏总胆固醇（TC）、血清TC、丙氨酸氨基转移酶、天冬氨酸氨基转移酶，减轻肝组织脂滴及炎性损伤。同时，还能上调PTEN的表达，下调PI 3 K和AKT的表达。本研究初步探讨了清肝活血方治疗ALD的作用靶点和作用途径，并初步验证了清肝活血方可能通过PTEN/PI 3 K/AKT信号通路改善ALD。
Qinggan Huoxue Recipe (QGHXR) is originated from Xiao Chaihu Decotion. Many experimental studies have confirmed that QGHXR can significantly alleviate the symptoms of alcoholic liver disease (ALD), but the detailed mechanism is still unclear. Using traditional Chinese medicine network pharmacology analysis system database and animal experiments, we found that 180 potentially chemical compositions and 618 potential targets were screened from the prescription, which shared 133 signal pathways with ALD. Through animal experiments, it was found that QGHXR could reduce the liver total cholesterol (TC), serum TC, alanine aminotransferase, aspartate aminotransferase of ALD mice, reduce the lipid droplets and inflammatory injury of liver tissue. Meanwhile, it can also increase PTEN, decrease PI3K and AKT mRNA levels. In this study, we obtained the targets and pathways of QGHXR in the treatment of ALD, and preliminatively verified that QGHXR may improve ALD through PTEN/PI3K/AKT signaling pathway.
登录
查看更多内容
影响因子：
5.6
作者：
Gao L;Chen X;Fu Z;Yin J;Wang Y;Sun W;Ren H;Zhang Y
通讯作者：
Zhang Y
影响因子：
--
作者：
Wang, Huifen;Zhang, Yanli;Du, Shiyu
通讯作者：
Du, Shiyu
中药清肝活血方通过脂多糖-枯否细胞信号传导通路保护大鼠酒精性肝病
影响因子：
2.7
作者：
Wu T;Liu T;Zhang L;Xing LJ;Zheng PY;Ji G
通讯作者：
Ji G
影响因子：
--
作者：
Subramaniyan V;Chakravarthi S;Jegasothy R;Seng WY;Fuloria NK;Fuloria S;Hazarika I;Das A
通讯作者：
Das A
影响因子：
14.8
作者：
通讯作者：
--