Stay (GI) Healthy: COVID-19 and Gastrointestinal Manifestations.
Stay (GI) Healthy: COVID-19 and Gastrointestinal Manifestations.
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DOI：
10.1016/j.tige.2021.01.006
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发表时间：
2021
影响因子：
2.4
通讯作者：
Aghemo A
中科院分区：
文献类型：
--
作者：
Vespa E;Pugliese N;Colapietro F;Aghemo A
SARS-CoV-2是导致新冠肺炎的病毒，其临床谱系广泛，无论是严重程度还是多器官性。SARS-CoV-2主要侵犯呼吸道，引起从流感样综合征到间质性肺炎和急性呼吸窘迫综合征。尽管其进入受体血管紧张素转换酶2通常在呼吸道上皮细胞中表达，但自疫情开始以来，一直显示肺外病变。新冠肺炎的胃肠道表现可能与血管紧张素转换酶2在消化道的大量表达有关。此外，不仅新冠肺炎患者经常出现胃肠道症状(腹泻、恶心/呕吐、腹痛)和肝脏检查异常，而且还有数据显示病毒在胃肠道复制活跃，可能是粪口传播。该综述的目的是总结有关新冠肺炎患者胃肠道受累和肝脏异常的患病率和临床意义的证据，为读者提供循证的建议。
SARS-CoV-2 is the virus responsible for COVID-19, whose clinical spectrum ranges widely, both in terms of severity and multi-organicity. SARS-CoV-2 mainly involves the respiratory tract, causing from a flu-like syndrome to interstitial pneumonia and acute respiratory distress syndrome. Although its entry receptor, angiotensin-converting-enzyme 2, is typically expressed in epithelial cells of the airways, extra-pulmonary involvement has been consistently demonstrated since the beginning of the outbreak. Gastrointestinal manifestations in COVID-19 may be explained by the abundant expression of ACE2 in the digestive tract. Moreover, not only COVID-19 patients often present with GI symptoms (diarrhea, nausea/vomiting, abdominal pain) and liver tests abnormalities, but there are also data showing active viral replication in the GI tract and possible fecal-oral transmission. Aim of this review is to summarize the evidence regarding prevalence and clinical significance of GI involvement and liver abnormalities in patients with COVID-19, providing the reader with evidence-based recommendations on the management of these conditions.
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影响因子：
19.7
作者：
Bhayana R;Som A;Li MD;Carey DE;Anderson MA;Blake MA;Catalano O;Gee MS;Hahn PF;Harisinghani M;Kilcoyne A;Lee SI;Mojtahed A;Pandharipande PV;Pierce TT;Rosman DA;Saini S;Samir AE;Simeone JF;Gervais DA;Velmahos G;Misdraji J;Kambadakone A
通讯作者：
Kambadakone A
DOI：
10.1016/s0140-6736(04)16255-7
发表时间：
2004-05-22
期刊：
Lancet (London, England)
影响因子：
--
作者：
Cheng PK;Wong DA;Tong LK;Ip SM;Lo AC;Lau CS;Yeung EY;Lim WW
通讯作者：
Lim WW
DOI：
10.1016/j.cgh.2020.09.041
发表时间：
2021-07
期刊：
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
影响因子：
--
作者：
Elmunzer BJ;Spitzer RL;Foster LD;Merchant AA;Howard EF;Patel VA;West MK;Qayed E;Nustas R;Zakaria A;Piper MS;Taylor JR;Jaza L;Forbes N;Chau M;Lara LF;Papachristou GI;Volk ML;Hilson LG;Zhou S;Kushnir VM;Lenyo AM;McLeod CG;Amin S;Kuftinec GN;Yadav D;Fox C;Kolb JM;Pawa S;Pawa R;Canakis A;Huang C;Jamil LH;Aneese AM;Glamour BK;Smith ZL;Hanley KA;Wood J;Patel HK;Shah JN;Agarunov E;Sethi A;Fogel EL;McNulty G;Haseeb A;Trieu JA;Dixon RE;Yang JY;Mendelsohn RB;Calo D;Aroniadis OC;LaComb JF;Scheiman JM;Sauer BG;Dang DT;Piraka CR;Shah ED;Pohl H;Tierney WM;Mitchell S;Condon A;Lenhart A;Dua KS;Kanagala VS;Kamal A;Singh VK;Pinto-Sanchez MI;Hutchinson JM;Kwon RS;Korsnes SJ;Singh H;Solati Z;Willingham FF;Yachimski PS;Conwell DL;Mosier E;Azab M;Patel A;Buxbaum J;Wani S;Chak A;Hosmer AE;Keswani RN;DiMaio CJ;Bronze MS;Muthusamy R;Canto MI;Gjeorgjievski VM;Imam Z;Odish F;Edhi AI;Orosey M;Tiwari A;Patwardhan S;Brown NG;Patel AA;Ordiah CO;Sloan IP;Cruz L;Koza CL;Okafor U;Hollander T;Furey N;Reykhart O;Zbib NH;Damianos JA;Esteban J;Hajidiacos N;Saul M;Mays M;Anderson G;Wood K;Mathews L;Diakova G;Caisse M;Wakefield L;Nitchie H;Waljee AK;Tang W;Zhang Y;Zhu J;Deshpande AR;Rockey DC;Alford TB;Durkalski V;North American Alliance for the Study of Digestive Manifestations of COVID-19
通讯作者：
North American Alliance for the Study of Digestive Manifestations of COVID-19
影响因子：
11.8
作者：
Corman, Victor M.;Albarrak, Ali M.;Memish, Ziad A.
通讯作者：
Memish, Ziad A.
影响因子：
7.3
作者：
Hamming, I;Timens, W;van Goor, H
通讯作者：
van Goor, H