Metals in biology: defining metalloproteomes.

Metals in biology: defining metalloproteomes.
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DOI:
10.1016/j.copbio.2011.11.005
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发表时间:
2012-02
影响因子:
7.7
通讯作者:
Tainer, John A.
Tainer, John A.
中科院分区:
工程技术1区
文献类型:
--
作者:
Yannone, Steven M.;Hartung, Sophia;Menon, Angeli L.;Adams, Michael W. W.;Tainer, John A.

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生物学中金属吸收和平衡的重要性质在高度进化的策略中是显而易见的,以促进生命所有三个领域的金属稳态。几十年来,对金属和金属蛋白的研究已经揭示了许多重要的生物金属功能。质谱、X射线散射/吸收和蛋白质组学的最新进展揭示了金属在生物学中比预期更广泛的用途。甚至铀、砷和铅等元素也与生物过程有关,这是生物金属新兴和广泛观点的一部分。在这里,我们讨论了建立和更新的方法来研究金属蛋白质的机会和挑战,重点是有望迅速扩大我们对金属蛋白质和金属功能的生物学知识的技术。
The vital nature of metal uptake and balance in biology is evident in the highly evolved strategies to facilitate metal homeostasis in all three domains of life. Several decades of study on metals and metalloproteins have revealed numerous essential bio-metal functions. Recent advances in mass spectrometry, x-ray scattering/absorption, and proteomics have exposed a much broader usage of metals in biology than expected. Even elements such as uranium, arsenic, and lead are implicated in biological processes as part of an emerging and expansive view of bio-metals. Here we discuss opportunities and challenges for established and newer approaches to study metalloproteins with a focus on technologies that promise to rapidly expand our knowledge of metalloproteins and metal functions in biology.
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