25-hydroxyvitamin D levels, vitamin D binding protein gene polymorphisms and incident coronary heart disease among whites and blacks: The ARIC study.
25-hydroxyvitamin D levels, vitamin D binding protein gene polymorphisms and incident coronary heart disease among whites and blacks: The ARIC study.
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DOI：
10.1016/j.atherosclerosis.2015.04.803
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发表时间：
2015-07
期刊：
影响因子：
5.3
通讯作者：
Lutsey, Pamela L.
中科院分区：
文献类型：
--
作者：
Michos, Erin D.;Misialek, Jeffrey R.;Selvin, Elizabeth;Folsom, Aaron R.;Pankow, James S.;Post, Wendy S.;Lutsey, Pamela L.
在观察性研究中，低 25-羟基维生素 D (25(OH)D) 与冠心病 (CHD) 风险增加有关，并且这种关联可能因种族而异。尽管 25(OH)D 平均值较低，但维生素 D 结合蛋白 (DBP) 单核苷酸多态性 (SNP) 频率的种族差异可能是黑人生物利用度维生素 D 相似的原因。我们假设，在白人以及基因型与较高 DBP 水平相关的人群中，低 25(OH)D 与 CHD 风险的关联性更强。我们通过质谱法测量了 ARIC 研究的 11,945 名参与者（基线 1990-1992 年，平均年龄 57 岁，59% 女性，24% 黑人）的 25(OH)D。对两个 DBP SNP（rs7041；rs4588）进行了基因分型。我们使用调整后的 Cox 比例风险模型来检查 25(OH)D 与截至 2011 年 12 月已判定的 CHD 事件的关联。在 20 年的中位数时间里，共发生了 1230 起 CHD 事件。在对人口统计和行为/社会经济因素（与种族=0.22）。在进一步调整这种关联的潜在介质（即糖尿病、高血压）后，白人的结果不再显着。 25(OH)D 与 DBP SNP rs4588 (p=0.92) 或 rs7041 (p=0.87) 与 CHD 风险之间没有统计学上显着的相互作用。低 25(OH)D 与白人中的冠心病 (CHD) 相关，但未发现 25(OH)D 与关键 DBP 基因型之间存在相互作用。
In observational studies, low 25-hydroxyvitamin D (25(OH)D) has been associated with increased risk of coronary heart disease (CHD), and this association may vary by race. Racial differences in the frequency of vitamin D binding protein (DBP) single nucleotide polymorphisms (SNPs) might account for similar bioavailable vitamin D in blacks despite lower mean 25(OH)D. We hypothesized that the associations of low 25(OH)D with CHD risk would be stronger among whites and among persons with genotypes associated with higher DBP levels. We measured 25(OH)D by mass spectroscopy in 11,945 participants in the ARIC Study (baseline 1990–1992, mean age 57 years, 59% women, 24% black). Two DBP SNPs (rs7041; rs4588) were genotyped. We used adjusted Cox proportional hazards models to examine the association of 25(OH)D with adjudicated CHD events through December 2011. Over a median of 20 years, there were 1230 incident CHD events. Whites in the lowest quintile of 25(OH)D (<17 ng/ml) compared to the upper 4 quintiles had an increased risk of incident CHD (HR 1.28, 95% CI 1.05–1.56), but blacks did not (1.03, 0.82–1.28), after adjustment for demographics and behavioral/socioeconomic factors (p-interaction with race=0.22). Results among whites were no longer significant after further adjustment for potential mediators of this association (i.e. diabetes, hypertension). There was no statistically significant interaction of 25(OH)D with the DBP SNPs rs4588 (p=0.92) or rs7041 (p=0.87) in relation to CHD risk. Low 25(OH)D was associated with incident CHD in whites, but no interactions of 25(OH)D with key DBP genotypes was found.
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影响因子：
37.8
作者：
Go AS;Mozaffarian D;Roger VL;Benjamin EJ;Berry JD;Blaha MJ;Dai S;Ford ES;Fox CS;Franco S;Fullerton HJ;Gillespie C;Hailpern SM;Heit JA;Howard VJ;Huffman MD;Judd SE;Kissela BM;Kittner SJ;Lackland DT;Lichtman JH;Lisabeth LD;Mackey RH;Magid DJ;Marcus GM;Marelli A;Matchar DB;McGuire DK;Mohler ER 3rd;Moy CS;Mussolino ME;Neumar RW;Nichol G;Pandey DK;Paynter NP;Reeves MJ;Sorlie PD;Stein J;Towfighi A;Turan TN;Virani SS;Wong ND;Woo D;Turner MB;American Heart Association Statistics Committee and Stroke Statistics Subcommittee
通讯作者：
American Heart Association Statistics Committee and Stroke Statistics Subcommittee
DOI：
10.1056/nejmoa1114248
发表时间：
2012-07-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Inker LA;Schmid CH;Tighiouart H;Eckfeldt JH;Feldman HI;Greene T;Kusek JW;Manzi J;Van Lente F;Zhang YL;Coresh J;Levey AS;CKD-EPI Investigators
通讯作者：
CKD-EPI Investigators
影响因子：
4
作者：
Gutierrez, O. M.;Farwell, W. R.;Kermah, D.;Taylor, E. N.
通讯作者：
Taylor, E. N.
影响因子：
7.1
作者：
Schleithoff, SS;Zittermann, A;Koerfer, R
通讯作者：
Koerfer, R
影响因子：
37.8
作者：
Oh J;Weng S;Felton SK;Bhandare S;Riek A;Butler B;Proctor BM;Petty M;Chen Z;Schechtman KB;Bernal-Mizrachi L;Bernal-Mizrachi C
通讯作者：
Bernal-Mizrachi C