Racial differences in the relationship between vitamin D, bone mineral density, and parathyroid hormone in the National Health and Nutrition Examination Survey.
Racial differences in the relationship between vitamin D, bone mineral density, and parathyroid hormone in the National Health and Nutrition Examination Survey.
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DOI：
10.1007/s00198-010-1383-2
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发表时间：
2011-06
影响因子：
4
通讯作者：
Taylor, E. N.
中科院分区：
文献类型：
--
作者：
Gutierrez, O. M.;Farwell, W. R.;Kermah, D.;Taylor, E. N.
目前尚不清楚白人体内25-羟基维生素D(25(OH)D)的最佳水平是否与少数族裔相同。在NHANES的成年参与者中，黑人与白人和墨西哥裔美国人相比，25(OH)D、骨密度(BMD)和甲状旁腺激素(PTH)之间的关系不同，这表明骨骼和矿物质代谢的最佳25(OH)D水平可能因种族而异。黑人和西班牙裔美国人的25-羟基维生素D浓度比白人低。然而，目前还不清楚白人的25(OH)D水平是否与少数民族人群的水平相同，这些水平被认为是白人骨骼和矿物质代谢的最佳水平。在2003-2004年和2005-2006年的国家健康和营养检查调查中，我们研究了8,415名成年参与者(25%黑人和24%墨西哥裔美国人)中25(OH)D和甲状旁腺激素之间的关系；在2003-2004年样本中，我们研究了25(OH)D和骨密度之间的关系。黑人和墨西哥裔美国人的25(OH)D显著低于白人，PTH浓度显著高于白人(P<；两者均为0.01)。在白人和墨西哥裔美国人中，随着血清25(OH)D和钙摄入量的下降，骨密度显著下降(P<；0.01)，但在黑人中没有下降(P=0.2)。维生素D缺乏(25(OH)D≤20 ng/ml)对甲状旁腺素水平的影响因种族/民族而改变(P代表交互作用，0.001)。在白人和墨西哥裔美国人中，25(OH)D水平高于和低于20 ng/ml的25(OH)D水平与甲状旁腺素呈负相关，而25(OH)D与甲状旁腺素之间的负相关仅在黑人中观察到，在这一临界点以上的斜率基本平坦(P=0.7)，这表明在低于白人或墨西哥裔美国人的25(OH)D水平下，甲状旁腺素可能受到最大程度的抑制。在美国成年人中，25(OH)D、BMD和甲状旁腺激素之间的关系可能因种族而异。是否需要特定种族的最佳维生素D范围来适当评估少数民族维生素D储存的充分性，还需要进一步研究。
It is unclear whether optimal levels of 25-hydroxyvitamin D (25(OH)D) in whites are the same as in minorities. In adult participants of NHANES, the relationships between 25(OH)D, bone mineral density (BMD), and parathyroid hormone (PTH) differed in blacks as compared to whites and Mexican-Americans, suggesting that optimal 25(OH)D levels for bone and mineral metabolism may differ by race. Blacks and Hispanics have lower 25-hydroxyvitamin D concentrations than whites. However, it is unclear whether 25(OH)D levels considered “optimal” for bone and mineral metabolism in whites are the same as those in minority populations. We examined the relationships between 25(OH)D and parathyroid hormone in 8,415 adult participants (25% black and 24% Mexican-American) in the National Health and Nutrition Examination Surveys 2003–2004 and 2005–2006; and between 25(OH)D and bone mineral density in 4,206 adult participants (24% black and 24% Mexican-American) in the 2003–2004 sample. Blacks and Mexican-Americans had significantly lower 25(OH)D and higher PTH concentrations than whites (P<0.01 for both). BMD significantly decreased (P<0.01) as serum 25(OH)D and calcium intake declined among whites and Mexican-Americans, but not among blacks (P=0.2). The impact of vitamin D deficiency (25 (OH)D≤20 ng/ml) on PTH levels was modified by race/ethnicity (P for interaction, 0.001). Whereas inverse relationships between 25(OH)D and PTH were observed above and below a 25(OH)D level of 20 ng/ml in whites and Mexican-Americans, an inverse association between 25(OH)D and PTH was only observed below this threshold in blacks, with the slope of the relationship being essentially flat (P=0.7) above this cut-point, suggesting that PTH may be maximally suppressed at lower 25(OH)D levels in blacks than in whites or Mexican-Americans. The relationships between 25(OH)D, BMD, and PTH may differ by race among US adults. Whether race-specific ranges of optimal vitamin D are needed to appropriately evaluate the adequacy of vitamin D stores in minorities requires further study.
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DOI：
10.1056/nejmoa0706130
发表时间：
2008-08-07
期刊：
The New England journal of medicine
影响因子：
--
作者：
Gutiérrez OM;Mannstadt M;Isakova T;Rauh-Hain JA;Tamez H;Shah A;Smith K;Lee H;Thadhani R;Jüppner H;Wolf M
通讯作者：
Wolf M
影响因子：
5.8
作者：
Hannan, Marian T.;Litman, Heather J.;Holick, Michael F.
通讯作者：
Holick, Michael F.
影响因子：
--
作者：
Aloia, JF;Talwar, SA;Yeh, J
通讯作者：
Yeh, J
影响因子：
4.2
作者：
Heaney, RP
通讯作者：
Heaney, RP
影响因子：
7.1
作者：
Harris, SS;Dawson-Hughes, B
通讯作者：
Dawson-Hughes, B