Tetrahymena thermophila, a unicellular eukaryote with separate germline and somatic genomes.

Tetrahymena thermophila, a unicellular eukaryote with separate germline and somatic genomes.
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DOI:
10.1016/j.resmic.2011.05.001
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发表时间:
2011-07
影响因子:
2.6
通讯作者:
Hamilton, Eileen P.
Hamilton, Eileen P.
中科院分区:
生物学3区
文献类型:
--
作者:
Orias, Eduardo;Cervantes, Marcella D.;Hamilton, Eileen P.

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Tetrahymena thermophila is a ciliate -- a unicellular eukaryote. Remarkably, every cell maintains differentiated germline and somatic genomes: one silent, the other expressed. Moreover, the two genomes undergo diverse processes, some as extreme as life and death, simultaneously in the same cytoplasm. Conserved eukaryotic mechanisms have been modified in ciliates to selectively deal with the two genomes. We describe research in several areas of Tetrahymena biology, including meiosis, amitosis, genetic assortment, selective nuclear pore transport, somatic RNAi-guided heterochromatin formation, DNA excision and programmed nuclear death by autophagy, which has enriched and broadened knowledge of those mechanisms.
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