Fame and future of faecal transplantations--developing next-generation therapies with synthetic microbiomes.
Fame and future of faecal transplantations--developing next-generation therapies with synthetic microbiomes.
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DOI：
10.1111/1751-7915.12047
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发表时间：
2013-07
影响因子：
5.7
通讯作者：
de Vos WM
中科院分区：
文献类型：
--
作者：
de Vos WM
虽然实践了一千多年，但目前有一个复兴的兴趣，利用粪便移植来改变患者的肠道微生物群。这种临床实践包括将大量各种形式的肠道微生物输送到接受者的肠道中，这些微生物通常已经被清除。粪便移植流行的主要原因是其治疗多种疾病的有效性。因此，有必要将这一程序发展到下一个水平。虽然在选择、标准化和储存供体微生物群方面有各种各样的进展，但了解肠道微生物群落并开发通过强大的生物技术过程提供这些微生物群的方法更具挑战性。本文讨论了已经采用的各种方法，也讨论了最小微生物组的概念以及合成群落的生产，这些合成群落可以在改变肠道微生物群的新治疗途径中发挥重要作用。
While practised for over thousand years, there is presently a renaissance in the interest of using of faecal transplantations to modify the intestinal microbiota of patients. This clinical practice consists of delivering large amounts of bowel microbes in various forms into the intestinal tract of the recipient that usually has been cleared previously. The major reason for the popularity of faecal transplantations is their effectiveness in treating a variety of diseases. Hence, there is a need to develop this procedure to the next level. While there are various developments to select, standardize and store the donor microbiota, it is more challenging to understand the intestinal microbial communities and develop ways to deliver these via robust biotechnological processes. The various approaches that have been followed to do so are discussed in this contribution that is also addressing the concept of the minimal microbiome as well as the production of the synthetic communities that can be instrumental in new therapeutic avenues to modify the intestinal microbiota.
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影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
12.3
作者：
Caporaso JG;Lauber CL;Costello EK;Berg-Lyons D;Gonzalez A;Stombaugh J;Knights D;Gajer P;Ravel J;Fierer N;Gordon JI;Knight R
通讯作者：
Knight R
影响因子：
4.4
作者：
Ben-Amor, K;Heilig, H;de Vos, WM
通讯作者：
de Vos, WM
影响因子：
12.2
作者：
Hamilton, Matthew J.;Weingarden, Alexa R.;Sadowsky, Michael J.
通讯作者：
Sadowsky, Michael J.
影响因子：
3.7
作者：
Borody, Thomas Julius;Campbell, Jordana
通讯作者：
Campbell, Jordana