Animal models in autoimmune diseases: lessons learned from mouse models for Sjögren's syndrome.
Animal models in autoimmune diseases: lessons learned from mouse models for Sjögren's syndrome.
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DOI：
10.1007/s12016-011-8288-5
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发表时间：
2012-02
影响因子：
9.1
通讯作者：
Cha, Seunghee
中科院分区：
文献类型：
--
作者：
Lee, Byung Ha;Gauna, Adrienne E.;Pauley, Kaleb M.;Park, Yun-Jong;Cha, Seunghee
小鼠模型是最常用和最成熟的动物模型之一，目前被用于许多研究领域。迄今为止，已利用各种小鼠模型来阐明多因素自身免疫性疾病的根本原因，包括病理性免疫成分和特定信号通路。本综述总结了最新的干燥综合征小鼠模型，干燥综合征是一种全身性自身免疫性疾病，其特征是外分泌腺（如唾液腺和泪腺）淋巴细胞浸润，以及分泌功能丧失，导致患者出现口干和眼干。尽管每种干燥综合征小鼠模型都类似于人类干燥综合征的主要症状或表型，但每种模型的特征都是可变的。此外，迄今为止还没有任何一种小鼠模型可以完全复制人类的条件。然而，每种小鼠模型的独特特征让我们深入了解潜在病因和免疫因素在干燥综合征发生和进展中的作用。在这里，我们将概述干燥综合征小鼠模型。这些小鼠模型的经验教训将帮助我们了解自身免疫性疾病中潜在的免疫失调，并将指导我们未来的研究方向为适当的诊断和治疗策略，以预测包括干燥综合征在内的自身免疫性疾病。
The mouse model is the one of the most frequently used and well-established animal models, and is currently used in many research areas. To date, various mouse models have been utilized to elucidate underlying causes of multi-factorial autoimmune conditions, including pathological immune components and specific signaling pathways. This review summarizes the more recent mouse models for Sjögren’s syndrome, a systemic autoimmune disease characterized by lymphocytic infiltration in the exocrine glands, such as the salivary and lacrimal glands, and loss of secretory function, resulting in dry mouth and dry eyes in patients. Although, every Sjögren’s syndrome mouse model resembles the major symptoms or phenotypes of Sjögren’s syndrome conditions in humans, the characteristics of each model are variable. Moreover, to date there is no single mouse model that can completely replicate the human conditions. However, unique features of each mouse model provide insights into the roles of potential etiological and immunological factors in the development and progression of Sjögren’s syndrome. Here, we will overview the Sjögren’s syndrome mouse models. Lessons from these mouse models will aid us to understand underlying immune dysregulation in autoimmune diseases in general, and will guide us to direct future research towards appropriate diagnostic and therapeutic strategies to predict autoimmune disease including Sjögren’s syndrome.
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DOI：
10.1073/pnas.90.13.6330
发表时间：
1993-07-01
影响因子：
11.1
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