Impact of Canal-Otolith Integration on Postural Control.
Impact of Canal-Otolith Integration on Postural Control.
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DOI：
10.3389/fnint.2021.773008
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发表时间：
2021
影响因子：
3.5
通讯作者：
Merfeld DM
中科院分区：
文献类型：
--
作者：
Wagner AR;Kobel MJ;Merfeld DM
滚动倾斜前庭感知阈值，前庭噪声的一种测试，最近被证明与健康老年人的次优平衡表现有关。然而，尽管这种相关性很强，但使用绝对的(即通过/不通过)平衡评估限制了对前庭噪音对姿势摆动的影响的洞察。因此，对这种相关性的解释还有待确定。我们假设翻滚倾斜前庭阈值和姿势控制之间的相关性反映了感官噪声的共同影响。为了解决这一假设，我们测量了33名健康年轻人在多个频率(0.2赫兹、0.5赫兹、1赫兹)下的翻滚感觉阈值，并将每个阈值与安静姿势控制的定量测量进行了比较(平均值=24.9岁，SD=3.67)。我们的数据显示，0.5赫兹的翻滚倾斜阈值与内侧(ML；β=5.31，p=0.002，95%CI=2.18.5)压力中心的均方根距离呈显著的线性相关，但与前后(AP；β=5.13p=0.016，95%CI=1.039.23)方向(Bonferroni校正的α=0.006)无关。相反，在0.2赫兹和1赫兹测量的前庭阈值与ML或AP RMSD没有明显的相关性。在多变量回归模型中，同时控制0.2Hz值和1Hz值后，0.5Hz值的显著影响仍然存在(β=5.44，p=0.029，CI=0.6010.28)，这表明这种影响不能用这三个频率下测量的前庭阈值所共有的因素来解释。这些数据表明，当视觉和本体感觉线索退化(即闭上眼睛，站在泡沫上)时，前庭噪音与内侧平面对安静姿势的时间空间控制显著相关。此外，安静的站姿摇摆与0.5赫兹的翻滚倾斜阈值的选择性关联，而不是在较低(0.2赫兹)或较高(1.0赫兹)频率下测量的阈值，可能反映了噪声的影响，该噪声是噪声通道和耳石线索的时间整合所产生的。
Roll tilt vestibular perceptual thresholds, an assay of vestibular noise, have recently been shown to be associated with suboptimal balance performance in healthy older adults. However, despite the strength of this correlation, the use of a categorical (i.e., pass/fail) balance assessment limits insight into the impacts of vestibular noise on postural sway. As a result, an explanation for this correlation has yet to be determined. We hypothesized that the correlation between roll tilt vestibular thresholds and postural control reflects a shared influence of sensory noise. To address this hypothesis, we measured roll tilt perceptual thresholds at multiple frequencies (0.2 Hz, 0.5 Hz, 1 Hz) and compared each threshold to quantitative measures of quiet stance postural control in 33 healthy young adults (mean = 24.9 years, SD = 3.67). Our data showed a significant linear association between 0.5 Hz roll tilt thresholds and the root mean square distance (RMSD) of the center of pressure in the mediolateral (ML; β = 5.31, p = 0.002, 95% CI = 2.1–8.5) but not anteroposterior (AP; β = 5.13, p = 0.016, 95% CI = 1.03–9.23) direction (Bonferroni corrected α of 0.006). In contrast, vestibular thresholds measured at 0.2 Hz and 1 Hz did not show a significant correlation with ML or AP RMSD. In a multivariable regression model, controlling for both 0.2 Hz and 1 Hz thresholds, the significant effect of 0.5 Hz roll tilt thresholds persisted (β = 5.44, p = 0.029, CI = 0.60–10.28), suggesting that the effect cannot be explained by elements shared by vestibular thresholds measured at the three frequencies. These data suggest that vestibular noise is significantly associated with the temporospatial control of quiet stance in the mediolateral plane when visual and proprioceptive cues are degraded (i.e., eyes closed, standing on foam). Furthermore, the selective association of quiet-stance sway with 0.5 Hz roll tilt thresholds, but not thresholds measured at lower (0.2 Hz) or higher (1.0 Hz) frequencies, may reflect the influence of noise that results from the temporal integration of noisy canal and otolith cues.
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