Mechanism of T-oligo-induced cell cycle arrest in Mia-PaCa pancreatic cancer cells.
Mechanism of T-oligo-induced cell cycle arrest in Mia-PaCa pancreatic cancer cells.
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DOI：
10.1002/jcp.22997
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发表时间：
2012-06
影响因子：
5.6
通讯作者：
Faller, Douglas V.
中科院分区：
文献类型：
--
作者：
Rankin, Andrew M.;Sarkar, Sibaji;Faller, Douglas V.
DNA oligonucleotides with sequence homology to human telomeric DNA (T-oligo) induce cell cycle arrest, followed by apoptosis, senescence, or autophagy in a human cancer cell type-specific manner. T-oligo has potential as a new therapeutic strategy in oncology because of its ability to target certain types of tumor cells while sparing normal ones. In the present study, we demonstrate the T-oligo-induced S-phase cell cycle arrest in four pancreatic cancer cell lines. To further contribute to the mechanistic understanding of T-oligo, we also identify cyclin dependent kinase 2 (cdk2) as a functional mediator in the T-oligo-induced cell cycle arrest of pancreatic cancer cells. Ectopic expression of a constitutively-active cdk2 mutant abrogates T-oligo-induced cell cycle arrest in these tumor cells while knockdown of cdk2 expression alone recapitulates the T-oligo effect. Finally, we demonstrate the dispensability of T-oligo-induced ATM/ATR-mediated DNA damage response-signaling pathways, which have long been considered functional in the T-oligo signaling mechanism.
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影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
影响因子：
10.5
作者：
Montagnoli, A;Fiore, F;Pagano, M
通讯作者：
Pagano, M
影响因子：
21.3
作者：
Jazayeri, A;Falck, J;Jackson, SP
通讯作者：
Jackson, SP
DOI：
10.1073/pnas.0235444100
发表时间：
2003-01-21
影响因子：
11.1
作者：
Li, GZ;Eller, MS;Gilchrest, BA
通讯作者：
Gilchrest, BA
影响因子：
15.3
作者：
Cuadrado, M;Martinez-Pastor, B;Fernandez-Capetillo, O
通讯作者：
Fernandez-Capetillo, O