Cardioventilatory Coupling in Resting Human Subjects
Cardioventilatory Coupling in Resting Human Subjects
复制标题
静息人体受试者的心肺通气耦合
DOI：
10.1113/eph8802606
复制
发表时间：
2003
影响因子：
2.7
通讯作者：
D. Galletly
中科院分区：
文献类型：
--
作者：
Y. Tzeng;P. Larsen;D. Galletly
在48个有意识的休息科目，我们研究了时间耦合的心跳计时和吸气（心脏起搏耦合）的开始，耦合和自主神经功能的光谱指数之间的关系。使用RI-1间期（吸气和前一个ECG R波之间的间期）的比例香农熵（SHα）作为耦合的度量，我们在48名受试者中的32名中检测到统计学显著的耦合。这一点通过目视检查RI间期的时间序列图得到证实，其中耦合明显为水平条带。耦合导致在一个显着的偏好为整数心率/呼吸频率比。最强的耦合与高（0.15 - 0.40 Hz）和低（0.04 - 0.15 Hz）频率范围内的低反射频率和高心率变异性相关，但与血压变异性或压力反射敏感性的光谱测量（α指数，低频范围）无关。雄性和雌性之间的偶联强度无差异。我们以前曾描述过在自主呼吸的麻醉受试者中的心脏复律偶联。目前的研究扩展了这些观察结果，证明在麻醉过程中看到的耦合的定性特征，也观察到在意识状态。我们的结论是耦合在正常生理呼吸控制的作用需要更广泛的探索。
In 48 conscious resting subjects we examined the temporal coupling of heart beat timing and the onset of inspiration (cardioventilatory coupling), and the relationship between coupling and spectral indices of autonomic function. Using the proportional Shannon entropy (SHα) of the RI‐1 interval (interval between inspiration and the preceding ECG R wave) as a measure of coupling we detected statistically significant coupling in 32 of the 48 subjects. This was confirmed by visual inspection of time series plots of RI intervals, in which coupling was evident as horizontal banding. Coupling resulted in a significant preference for whole number heart rate/respiratory frequency ratios. The strongest coupling was associated with low ventilatory frequency and high heart rate variability in the high (0.15‐0.40 Hz) and low (0.04‐0.15 Hz) frequency ranges, but was not related to blood pressure variability, or to a spectral measure of baroreflex sensitivity (α‐index, low frequency range). There was no difference in coupling strength between males and females. We have previously described cardioventilatory coupling in spontaneously breathing anaesthetised subjects. The current study extends those observations by demonstrating that the qualitative features of coupling seen during anaesthesia are also observed in the conscious state. We conclude that the role of coupling in normal physiological respiratory control needs to be more widely explored.
DOI：
10.1016/s0034-5687(00)00155-9
发表时间：
2000-09-01
期刊：
RESPIRATION PHYSIOLOGY
影响因子：
--
作者：
Smith, JC;Butera, RJ;Johnson, SM
通讯作者：
Johnson, SM
影响因子：
2.4
作者：
Kotani, K;Takamasu, K;Yamamoto, Y
通讯作者：
Yamamoto, Y