Metabolic Mechanisms in Obesity and Type 2 Diabetes: Insights from Bariatric/Metabolic Surgery.
Metabolic Mechanisms in Obesity and Type 2 Diabetes: Insights from Bariatric/Metabolic Surgery.
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DOI：
10.1159/000441259
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发表时间：
2015
期刊：
影响因子：
3.6
通讯作者：
Busetto L
中科院分区：
文献类型：
--
作者：
Cătoi AF;Pârvu A;Mureşan A;Busetto L
肥胖症和相关的糖尿病流行是全世界真实的问题。近年来，减肥/代谢手术作为肥胖和相关疾病（包括2型糖尿病（T2 DM））的一种有价值的治疗选择出现。肥胖和T2 DM的复杂机制网络尚未完全确定。对于哪种代谢缺陷是导致代谢恶化的第一个代谢缺陷：胰岛素抵抗还是高胰岛素血症仍存在争议。对减肥/代谢手术的代谢效应的深入了解表明，除了体重减轻和食物限制外，胃肠道的重排还可以激活其他机制，如肠促胰岛素/抗肠促胰岛素系统、胆汁酸组成和流量的变化以及肠道微生物群的改变;所有这些都可能参与T2 DM的缓解。这些机制的完整阐明将导致更好地了解这种疾病的发病机制。我们的目的是审查参与肥胖患者T2 DM发展的代谢机制，以及接受减肥/代谢手术的患者病情缓解的代谢机制。
Obesity and the related diabetes epidemics represent a real concern worldwide. Bariatric/metabolic surgery emerged in last years as a valuable therapeutic option for obesity and related diseases, including type 2 diabetes mellitus (T2DM). The complicated network of mechanisms involved in obesity and T2DM have not completely defined yet. There is still a debate on which would be the first metabolic defect leading to metabolic deterioration: insulin resistance or hyperinsulinemia? Insight into the metabolic effects of bariatric/metabolic surgery has revealed that, beyond weight loss and food restriction, other mechanisms can be activated by the rearrangements of the gastrointestinal tract, such as the incretinic/anti-incretinic system, changes in bile acid composition and flow, and modifications of gut microbiota; all of them possibly involved in the remission of T2DM. The complete elucidation of these mechanisms will lead to a better understanding of the pathogenesis of this disease. Our aim was to review some of the metabolic mechanisms involved in the development of T2DM in obese patients as well as in the remission of this condition in patients submitted to bariatric/metabolic surgery.
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影响因子：
16.2
作者：
Gerhard GS;Styer AM;Wood GC;Roesch SL;Petrick AT;Gabrielsen J;Strodel WE;Still CD;Argyropoulos G
通讯作者：
Argyropoulos G
影响因子：
4.2
作者：
Argyropoulos, George
通讯作者：
Argyropoulos, George
影响因子：
2.9
作者：
Bradnova, Olga;Kyrou, Ioannis;Vrbikova, Jana
通讯作者：
Vrbikova, Jana
影响因子：
4.9
作者：
Ahmad, N. N.;Pfalzer, A.;Kaplan, L. M.
通讯作者：
Kaplan, L. M.
影响因子：
7.7
作者：
Furet JP;Kong LC;Tap J;Poitou C;Basdevant A;Bouillot JL;Mariat D;Corthier G;Doré J;Henegar C;Rizkalla S;Clément K
通讯作者：
Clément K