Role of tyrosine-sulfated proteins in retinal structure and function.
Role of tyrosine-sulfated proteins in retinal structure and function.
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DOI：
10.1016/j.exer.2014.07.007
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发表时间：
2015-04
影响因子：
3.4
通讯作者：
Al-Ubaidi, M. R.
中科院分区：
文献类型：
--
作者：
Kanan, Y.;Al-Ubaidi, M. R.
细胞外基质（ECM）在细胞和视网膜健康中起着重要作用。视网膜酪氨酸硫酸化蛋白的研究是了解ECM在视网膜健康和疾病中作用的重要第一步。这些分泌的蛋白质是视网膜ECM的成员。酪氨酸硫酸化被证明是必要的适当的视网膜结构和功能的发展。酪氨酸硫酸化的重要性进一步通过酪氨酰蛋白磺基转移酶（催化蛋白质酪氨酸硫酸化的酶）的进化存在以及这些酶的补偿能力来证明。研究已经确定了四种酪氨酸硫酸化视网膜蛋白：fibulin 2，vitronectin，补体因子H（CFH）和opticin。玻连蛋白和CFH调节补体系统的激活，并参与一些年龄相关性黄斑变性病例的病因学。对酪氨酸硫酸化在纤蛋白功能中的作用的分析表明，硫酸化影响蛋白质调节生长和迁移的能力。虽然opticin最近被证明具有抗血管生成的特性，但尚未确定硫酸化在该功能中起什么作用。未来的研究重点是确定所有的酪氨酸硫酸化视网膜蛋白将有助于确定硫酸化视网膜蛋白功能的视网膜稳态和疾病。
The extracellular matrix (ECM) plays a significant role in cellular and retinal health. The study of retinal tyrosine-sulfated proteins is an important first step toward understanding the role of ECM in retinal health and diseases. These secreted proteins are members of the retinal ECM. Tyrosine sulfation was shown to be necessary for the development of proper retinal structure and function. The importance of tyrosine sulfation is further demonstrated by the evolutionary presence of tyrosylprotein sulfotransferases, enzymes that catalyze proteins’ tyrosine sulfation, and the compensatory abilities of these enzymes. Research has identified four tyrosine-sulfated retinal proteins: fibulin 2, vitronectin, complement factor H (CFH), and opticin. Vitronectin and CFH regulate the activation of the complement system and are involved in the etiology of some cases of age-related macular degeneration. Analysis of the role of tyrosine sulfation in fibulin function showed that sulfation influences the protein's ability to regulate growth and migration. Although opticin was recently shown to exhibit anti-angiogenic properties, it is not yet determined what role sulfation plays in that function. Future studies focusing on identifying all of the tyrosine-sulfated retinal proteins would be instrumental in determining the impact of sulfation on retinal protein function in retinal homeostasis and diseases.
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DOI：
10.1073/pnas.0501536102
发表时间：
2005-05-17
影响因子：
11.1
作者：
Hageman, GS;Anderson, DH;Allikmets, R
通讯作者：
Allikmets, R
影响因子：
5.3
作者：
Colvin, Richard A.;Campanella, Gabriele S. V.;Luster, Andrew D.
通讯作者：
Luster, Andrew D.
影响因子：
13.8
作者：
Boehncke, WH;Schön, MP
通讯作者：
Schön, MP
影响因子：
56.9
作者：
Edwards, AO;Ritter, R;Farrer, LA
通讯作者：
Farrer, LA
DOI：
10.1073/pnas.80.15.4747
发表时间：
1983-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
CHANDRASEKHAR, S;SORRENTINO, JA;MILLIS, AJT
通讯作者：
MILLIS, AJT