Default mode network deactivation to smoking cue relative to food cue predicts treatment outcome in nicotine use disorder.
Default mode network deactivation to smoking cue relative to food cue predicts treatment outcome in nicotine use disorder.
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DOI：
10.1111/adb.12498
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发表时间：
2018-01
影响因子：
3.4
通讯作者：
Hutchison KE
中科院分区：
文献类型：
--
作者：
Wilcox CE;Claus ED;Calhoun VD;Rachakonda S;Littlewood RA;Mickey J;Arenella PB;Goodreau N;Hutchison KE
确定尼古丁使用障碍（NUD）治疗结果的预测因素可能有助于提高现有治疗方法（如伐尼克兰）的疗效。在一些研究中，大脑对药物刺激的反应可以预测尼古丁和其他物质使用障碍的复发风险。默认模式网络（DMN）的活动受到药物线索和其他可口线索的影响，但其临床意义尚不清楚。在这项研究中，143名尼古丁使用障碍（NUD）患者（男性n=91，年龄18-55）在视觉提示任务期间接受了功能性MRI扫描，在此期间，他们在随机接受伐尼克兰（n=80）或安慰剂治疗之前接受了一系列吸烟或食物相关的视频剪辑。组独立成分分析被用来隔离的DMN，和时间排序被用来计算的DMN BOLD信号之间的差异，在烟雾与食物的线索，为每个人。食物线索与更大的失活相比，在DMN的烟雾线索。校正基线吸烟和其他临床变量，这些变量在先前的工作中已被证明与治疗结果相关，当两个治疗组合并时，较低的吸烟-食物差异评分预测第6周和第12周的吸烟率较高（p=0.005，β =-0.766）。执行控制（ECN）和显着性网络的探索性分析表明，更积极的ECN烟-食物差异评分预测伐尼克兰相对于安慰剂更稳健的反应。这些发现进一步支持了大脑对可口线索的反应性，特别是在DMN中，可能与NUD有直接的临床相关性的理论。
Identifying predictors of treatment outcome for nicotine use disorders (NUD) may help improve efficacy of established treatments, like varenicline. Brain reactivity to drug-stimuli predicts relapse risk in nicotine and other substance use disorders in some studies. Activity in the default mode network (DMN) is affected by drug cues and other palatable cues, but its clinical significance is unclear. In this study, 143 individuals with nicotine use disorder (NUD) (male n=91, ages 18–55) received a functional MRI scan during a visual cue task during which they were presented with a series of smoking- or food-related video clips prior to randomization to treatment with varenicline (n=80) or placebo. Group independent components analysis was utilized to isolate the DMN, and temporal sorting was used to calculate the difference between the DMN BOLD signal during smoke versus food cues for each individual. Food cues were associated with greater deactivation compared to smoke cues in the DMN. Correcting for baseline smoking and other clinical variables which have been shown to be related to treatment outcome in previous work, a less positive Smoke-Food difference score predicted greater smoking at 6 and 12 weeks when both treatment groups were combined (p=0.005, beta=−0.766). An exploratory analysis of executive control (ECN) and salience networks demonstrated that a more positive Smoke-Food difference score for ECN predicted a more robust response to varenicline relative to placebo. These findings provide further support to theories that brain reactivity to palatable cues, and in particular in DMN, may have direct clinical relevance in NUD.
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影响因子：
25.8
作者：
Lerman, Caryn;Gu, Hong;Loughead, James;Ruparel, Kosha;Yang, Yihong;Stein, Elliot A.
通讯作者：
Stein, Elliot A.
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
--
作者：
Franklin, Teresa;Wang, Ze;Suh, Jesse J.;Hazan, Rebecca;Cruz, Jeffrey;Li, Yin;Goldman, Marina;Detre, John A.;O'Brien, Charles P.;Childress, Anna Rose
通讯作者：
Childress, Anna Rose
影响因子：
2.7
作者：
Higgins, Julian P. T.;White, Ian R.;Wood, Angela M.
通讯作者：
Wood, Angela M.
影响因子：
6
作者：
Aubin, HJ;Lebargy, F;Lagrue, G
通讯作者：
Lagrue, G