Orbitofrontal reward sensitivity and impulsivity in adult attention deficit hyperactivity disorder
Orbitofrontal reward sensitivity and impulsivity in adult attention deficit hyperactivity disorder
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成人注意力缺陷多动障碍的眶额奖赏敏感性和冲动性
DOI：
10.1016/j.neuroimage.2011.12.011
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发表时间：
2012
期刊：
影响因子：
5.7
通讯作者：
Blechert
中科院分区：
文献类型：
--
作者：
Wilbertz;Tebartz van Eist;Delgado;Philipsen;Blechert
成人注意力缺陷多动障碍（ADHD）的冲动性症状，如冒险行为增加，与奖励处理受损有关。以前的研究集中在奖励预期或奖励执行功能任务，并描述了成年和青少年ADHD的纹状体低反应性和眶额改变。被动奖励传递及其与行为冲动的联系还不太清楚。为了研究奖励处理的这一关键方面，我们使用功能性磁共振成像（fMRI）结合皮肤电评估在男性和女性成人ADHD患者（N=28）和匹配的健康对照参与者（N=28）在交付的货币和非货币奖励。此外，两个行为任务评估风险决策（骰子游戏任务）和延迟折扣。结果表明，两组激活腹侧和背侧纹状体和内侧眶额皮质（mOFC）在响应高激励（即金钱）奖励。一个类似的，但不太强的激活模式被发现为低激励（即非货币）奖励。组间差异出现时，直接比较高和低的激励奖励：激活的mOFC编码的动机变化，奖励交付在健康对照组，但不是ADHD患者。此外，患者中这种功能失调的mOFC活动与风险决策和延迟折扣相关，并被生理唤醒所掩盖。总之，这些结果表明，mOFC在健康个体中编码奖励值和类型，而在ADHD中这种功能是缺乏的。脑行为相关性表明，这种缺陷可能与行为冲动有关。在研究和应用环境中评估奖励预期和情绪学习时，应考虑ADHD的奖励价值加工困难。
Impulsivity symptoms of adult attention deficit hyperactivity disorder (ADHD) such as increased risk taking have been linked with impaired reward processing. Previous studies have focused on reward anticipation or on rewarded executive functioning tasks and have described a striatal hyporesponsiveness and orbitofrontal alterations in adult and adolescent ADHD. Passive reward delivery and its link to behavioral impulsivity are less well understood. To study this crucial aspect of reward processing we used functional magnetic resonance imaging (fMRI) combined with electrodermal assessment in male and female adult ADHD patients (N=28) and matched healthy control participants (N=28) during delivery of monetary and non-monetary rewards. Further, two behavioral tasks assessed risky decision making (game of dice task) and delay discounting. Results indicated that both groups activated ventral and dorsal striatum and the medial orbitofrontal cortex (mOFC) in response to high-incentive (i.e. monetary) rewards. A similar, albeit less strong activation pattern was found for low-incentive (i.e. non-monetary) rewards. Group differences emerged when comparing high and low incentive rewards directly: activation in the mOFC coded for the motivational change in reward delivery in healthy controls, but not ADHD patients. Additionally, this dysfunctional mOFC activity in patients correlated with risky decision making and delay discounting and was paralleled by physiological arousal. Together, these results suggest that the mOFC codes reward value and type in healthy individuals whereas this function is deficient in ADHD. The brain–behavior correlations suggest that this deficit might be related to behavioral impulsivity. Reward value processing difficulties in ADHD should be considered when assessing reward anticipation and emotional learning in research and applied settings.
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DOI：
--
发表时间：
1970
期刊：
--
影响因子：
--
作者：
C. Spielberger;R. Gorsuch;R. Lushene
通讯作者：
C. Spielberger;R. Gorsuch;R. Lushene
DOI：
10.1073/pnas.0912838107
发表时间：
2010-03-30
影响因子：
11.1
作者：
Kahnt, Thorsten;Heinzle, Jakob;Haynes, John-Dylan
通讯作者：
Haynes, John-Dylan
冲动的行为成分可以预测患有多动症的成年人和健康对照者的饮酒量。
影响因子：
4.2
作者：
Weafer,Jessica;Milich,Richard;Fillmore,MarkT
通讯作者：
Fillmore,MarkT
儿童轻微脑功能障碍综合征：I——该综合征及其与精神病学的相关性 II——该综合征的心理和生物化学模型
影响因子：
1.9
作者：
P. Wender
通讯作者：
P. Wender
Fragebogen zur Lebenszufriedenheit (FLZ)。
DOI：
--
发表时间：
2001
期刊：
影响因子：
--
作者：
V. Exner
通讯作者：
V. Exner