Visual perception and its impairment in schizophrenia.
Visual perception and its impairment in schizophrenia.
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DOI：
10.1016/j.biopsych.2008.03.023
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发表时间：
2008-07-01
影响因子：
10.6
通讯作者：
Dakin SC
中科院分区：
文献类型：
--
作者：
Butler PD;Silverstein SM;Dakin SC
精神分裂症的认知神经科学中的许多工作都集中在注意力、记忆和执行功能上。到目前为止，较少的研究集中在知觉处理上。然而，精神分裂症患者的知觉功能经常中断，因此这一领域已被纳入CNTRICS(认知神经科学治疗研究，以改善精神分裂症的认知)项目。在这篇文章中，我们描述了2007年2月26日和27日在马里兰州贝塞斯达举行的第一届CNTRICS会议上关于感知主题的基础科学报告和分组讨论。讨论了知觉障碍在精神分裂症中的重要性，这种障碍中知觉异常的性质，以及开发适合未来临床试验的知觉测试的迫切需要。虽然精神分裂症的听觉、嗅觉和躯体感觉处理也有缺陷，但第一次CNTRICS会议的重点是视觉处理缺陷。介绍了视觉感知中的增益控制和积分的关键概念。本文提供了这些概念的定义和示例。视觉增益控制和整合的使用符合CNTRICS委员会建议的一些标准，为理解精神分裂症的视觉系统提供了基本结构，并包括较低水平和较高水平的知觉缺陷。
Much work in the cognitive neuroscience of schizophrenia has focused on attention, memory, and executive functioning. To date, less work has focused on perceptual processing. However, perceptual functions are frequently disrupted in schizophrenia, and thus this domain has been included in the CNTRICS (Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia) project. In this article, we describe the basic science presentation and the breakout group discussion on the topic of perception from the first CNTRICS meeting, held in Bethesda, Maryland on February 26 and 27, 2007. The importance of perceptual dysfunction in schizophrenia, the nature of perceptual abnormalities in this disorder, and the critical need to develop perceptual tests appropriate for future clinical trials were discussed. Although deficits are also seen in auditory, olfactory, and somatosensory processing in schizophrenia, the first CNTRICS meeting focused on visual processing deficits. Key concepts of gain control and integration in visual perception were introduced. Definitions and examples of these concepts are provided in this article. Use of visual gain control and integration fit a number of the criteria suggested by the CNTRICS committee, provide fundamental constructs for understanding the visual system in schizophrenia, and are inclusive of both lower-level and higher-level perceptual deficits.
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影响因子：
4.6
作者：
Brenner, CA;Wilt, MA;O'Donnell, BF
通讯作者：
O'Donnell, BF
影响因子：
15.9
作者：
BODISWOLLNER, I
通讯作者：
BODISWOLLNER, I
影响因子：
10.6
作者：
Cadenhead, KS;Serper, Y;Braff, DL
通讯作者：
Braff, DL
DOI：
10.1073/pnas.86.23.9631
发表时间：
1989-12-01
影响因子：
11.1
作者：
CHUBB, C;SPERLING, G;SOLOMON, JA
通讯作者：
SOLOMON, JA
影响因子：
--
作者：
Butler, PD;Zemon, V;Javitt, DC
通讯作者：
Javitt, DC