Chemokine-ligands/receptors: multiplayers in traumatic spinal cord injury.
Chemokine-ligands/receptors: multiplayers in traumatic spinal cord injury.
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DOI：
10.1155/2015/486758
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发表时间：
2015
影响因子：
4.6
通讯作者：
Held-Feindt J
中科院分区：
文献类型：
--
作者：
Knerlich-Lukoschus F;Held-Feindt J
脊髓损伤（SCI）导致复杂的创伤后后遗症，影响整个神经轴。由于其参与各种神经调节过程，趋化因子-配体/受体-网络是SCI诱导的继发性损伤级联反应的关键因素。本综述将提供一个概要的趋化因子配体/受体表达沿着整个脊髓创伤（sc）的基础上，最近在体内和体外的研究结果，在脊髓损伤范式的胸部力量定义的影响病变（无限地平线撞击器）在成年大鼠的侮辱。在不同严重程度的sc损伤或假手术后的特定时间点分析趋化因子配体/受体表达，发现这些炎症介质在不同的解剖学sc区域和丘脑核、导水管周围灰质和大脑海马结构中被诱导。细胞和解剖学表达谱，以及成体干细胞壁龛中神经干/祖细胞标记物的共定位/表达，或与背角、背柱和疼痛处理脑区中疼痛相关受体和介质的共定位/表达，支持趋化因子参与临床创伤后损伤和综合征的独特级联反应的观点。这些方面和它们的含义在定制SCI治疗的概念进行了审查的背景下，最近的文献趋化因子配体/受体参与复杂的继发性病变级联反应。
Spinal cord injury (SCI) results in complex posttraumatic sequelae affecting the whole neuraxis. Due to its involvement in varied neuromodulatory processes, the chemokine-ligand/receptor-network is a key element of secondary lesion cascades induced by SCI. This review will provide a synopsis of chemokine-ligand/receptor-expression along the whole neuraxis after traumatic spinal cord (sc) insults on basis of recent in vivo and in vitro findings in a SCI paradigm of thoracic force-defined impact lesions (Infinite Horizon Impactor) in adult rats. Analyses of chemokine-ligand/receptor-expression at defined time points after sc lesion of different severity grades or sham operation revealed that these inflammatory mediators are induced in distinct anatomical sc regions and in thalamic nuclei, periaqueductal grey, and hippocampal structures in the brain. Cellular and anatomical expression profiles together with colocalization/expression of neural stem/progenitor cell markers in adult sc stem cells niches or with pain-related receptors and mediators in dorsal horns, dorsal columns, and pain-processing brain areas support the notion that chemokines are involved in distinct cascades underlying clinical posttraumatic impairments and syndromes. These aspects and their implication in concepts of tailored SCI treatment are reviewed in the context of the recent literature on chemokine-ligand/receptor involvement in complex secondary lesion cascades.
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影响因子：
2.7
作者：
Clark AK;Old EA;Malcangio M
通讯作者：
Malcangio M
DOI：
10.1124/jpet.107.135053
发表时间：
2008-05-01
影响因子：
3.5
作者：
Benamar, Khalid;Geller, Ellen B.;Adler, Martin W.
通讯作者：
Adler, Martin W.
DOI：
10.1016/j.apmr.2014.10.021
发表时间：
2015-04-01
影响因子：
4.3
作者：
Bank, Matthew;Stein, Adam;Bloom, Ona
通讯作者：
Bloom, Ona
DOI：
10.1073/pnas.0610811104
发表时间：
2007-06-19
影响因子：
11.1
作者：
Clark, Anna K.;Yip, Ping K.;Malcangio, Marzia
通讯作者：
Malcangio, Marzia
影响因子：
5
作者：
Benamar, Khalid;Geller, Ellen B.;Adler, Martin W.
通讯作者：
Adler, Martin W.