Epithelial sensing of microbiota-derived signals.
Epithelial sensing of microbiota-derived signals.
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DOI：
10.1038/s41435-021-00124-w
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发表时间：
2021-10
影响因子：
5
通讯作者：
Alenghat T
中科院分区：
文献类型：
--
作者：
Eshleman EM;Alenghat T
胃肠道内有数万亿种微生物，统称为微生物群，它们与宿主建立了共生关系。几十年的研究强调了微生物信号在宿主生理发育、成熟和功能中的必要性。然而，微生物群的组成或容纳的变化与几种慢性炎症性疾病的发展有关，包括炎症性肠病。肠上皮细胞（IEC）与微生物群持续接触，对维持肠道内稳态至关重要。来自微生物群的信号直接被IEC感知，并通过校准免疫细胞反应和强化肠道屏障功能来影响肠道健康。IEC通过参与常见的模式识别受体或通过感测微生物衍生代谢物的产生来检测肠道微生物。IEC中这些微生物检测途径的缺陷导致上皮屏障功能受损和肠道内稳态改变。这篇综述的目的是突出的途径，通过这些途径IEC的感觉微生物源性信号和必要性，这些检测途径在维持上皮屏障的完整性。
The gastrointestinal tract harbors trillions of microbial species, collectively termed the microbiota, which establish a symbiotic relationship with the host. Decades of research have emphasized the necessity of microbial signals in the development, maturation, and function of host physiology. However, changes in the composition or containment of the microbiota have been linked to the development of several chronic inflammatory diseases, including inflammatory bowel diseases. Intestinal epithelial cells (IECs) are in constant contact with the microbiota and are critical for maintaining intestinal homeostasis. Signals from the microbiota are directly sensed by IECs and influence intestinal health by calibrating immune cell responses and fortifying intestinal barrier function. IECs detect commensal microbes through engagement of common pattern recognition receptors or by sensing the production of microbial-derived metabolites. Deficiencies in these microbial-detecting pathways in IECs leads to impaired epithelial barrier function and altered intestinal homeostasis. This Review aims to highlight the pathways by which IECs sense microbiota-derived signals and the necessity of these detection pathways in maintaining epithelial barrier integrity.
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Alenghat, Theresa;Osborne, Lisa C.;Saenz, Steven A.;Kobuley, Dmytro;Ziegler, Carly G. K.;Mullican, Shannon E.;Choi, Inchan;Grunberg, Stephanie;Sinha, Rohini;Wynosky-Dolfi, Meghan;Snyder, Annelise;Giacomin, Paul R.;Joyce, Karen L.;Hoang, Tram B.;Bewtra, Meenakshi;Brodsky, Igor E.;Sonnenberg, Gregory F.;Bushman, Frederic D.;Won, Kyoung-Jae;Lazar, Mitchell A.;Artis, David
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