Cardiometabolic correlates of sleep disordered breathing in Andean highlanders.
Cardiometabolic correlates of sleep disordered breathing in Andean highlanders.
复制标题
DOI：
10.1183/13993003.01705-2016
复制
发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Schwartz AR
中科院分区：
文献类型：
--
作者：
Pham LV;Miele CH;Schwartz NG;Arias RS;Rattner A;Gilman RH;Miranda JJ;Polotsky VY;Checkley W;Schwartz AR
睡眠呼吸障碍（SDB）和心脏代谢结果之间的关系尚未在高地人中进行研究。我们在秘鲁高地人（3825米）进行了夜间多导描记术。多变量线性回归模型检查了SDB指标与血红蛋白、葡萄糖耐量（血红蛋白A1 c（HbA 1c）、空腹血糖和β细胞功能稳态模型评估（HOMA-β）和胰岛素抵抗（HOMA-IR））、血压和血脂之间的相关性，同时调整了年龄、性别、体重指数（BMI）和清醒氧合。参与者（n=187，91名男性）52岁（IQR 45-62），BMI为27.0 kg/m2（24.3-29.5），清醒时氧合血红蛋白饱和度为87%（85-88）。在完全校正的模型中，男性夜间低氧血症恶化与血红蛋白升高相关（p=0.03），与清醒氧合和呼吸暂停低通气指数（AHI）无关;而老年女性清醒氧合恶化与血红蛋白升高相关（p=0.02）。相反，AHI与HbA 1c升高独立相关（p<0.05）。在单变量模型中，夜间低氧血症与较高的HbA 1c、HOMA-IR和HOMA-β相关（p<0.001，=0.02和=0.04）;而AHI与HOMA-IR、收缩压和甘油三酯升高相关（p=0.02，=0.01和<0.01）。这些关联在完全调整的模型中并不显著。在高地人中，夜间低氧血症和睡眠呼吸暂停与不同的心脏代谢结果相关，分别赋予过度红细胞增多和葡萄糖耐受不良的不同风险。
Associations between sleep disordered breathing (SDB) and cardiometabolic outcomes have not been examined in highlanders. We performed nocturnal polygraphy in Peruvian highlanders (3825m). Multi-variable linear regression models examined associations between SDB metrics and hemoglobin, glucose tolerance (hemoglobin A1c (HbA1c), fasting glucose and homeostatic model assessment of β-cell function (HOMA-β) and insulin resistance (HOMA-IR)), blood pressure and lipids, while adjusting for age, sex, body-mass index (BMI) and wake oxygenation. Participants (n=187, 91 men) were 52 years-old (IQR 45–62), had BMI of 27.0 kg/m2 (24.3–29.5) and 87% (85–88) oxyhemoglobin saturation during wakefulness. In fully adjusted models, worsening nocturnal hypoxemia was associated with hemoglobin elevations in men (p=0.03), independent of wake oxygenation and apnea-hypopnea index (AHI); whereas worsening wake oxygenation was associated with hemoglobin elevations in older women (p=0.02). In contrast, AHI was independently associated with HbA1c elevations (p<0.05). In single-variable models, nocturnal hypoxemia was associated with higher HbA1c, HOMA-IR and HOMA-β (p<0.001, =0.02 and =0.04); whereas AHI was associated with HOMA-IR, systolic blood pressure and triglyceride elevations (p=0.02, =0.01, and <0.01). These associations were not significant in fully adjusted models. In highlanders, nocturnal hypoxemia and sleep apnea were associated with distinct cardiometabolic outcomes, conferring differential risk for excessive erythrocytosis and glucose intolerance, respectively.
登录
查看更多内容
影响因子：
39.2
作者：
FLICK, MR;BLOCK, AJ
通讯作者：
BLOCK, AJ
影响因子：
2.1
作者：
León-Velarde, F;Maggiorini, M;Zubieta-Calleja, G
通讯作者：
Zubieta-Calleja, G
DOI：
10.1164/ajrccm/145.5.1070
发表时间：
1992-05-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
FLETCHER, EC;LUCKETT, RA;COSTARANGOSGALARZA, C
通讯作者：
COSTARANGOSGALARZA, C
影响因子：
9.6
作者：
De Ferrari, Aldo;Miranda, J. Jaime;Checkley, William
通讯作者：
Checkley, William
影响因子：
37.8
作者：
Gottlieb DJ;Yenokyan G;Newman AB;O'Connor GT;Punjabi NM;Quan SF;Redline S;Resnick HE;Tong EK;Diener-West M;Shahar E
通讯作者：
Shahar E