A comprehensive review on potential therapeutics interventions for COVID-19.
A comprehensive review on potential therapeutics interventions for COVID-19.
复制标题
DOI：
10.1016/j.ejphar.2020.173741
复制
发表时间：
2021-01-05
影响因子：
5
通讯作者：
Chandra R
中科院分区：
文献类型：
--
作者：
Chugh H;Awasthi A;Agarwal Y;Gaur RK;Dhawan G;Chandra R
COVID-19 是由 SARS-CoV-2（一种在中国武汉出现的新型 β 冠状病毒）引起的传染性呼吸道疾病。它主要是一种呼吸道疾病，很容易通过直接和间接接触传播。它在不同的个体中表现出一系列症状，因此被分为轻度、中度和重度疾病。该病毒利用其表面的刺突蛋白识别宿主细胞上的 ACE-2 受体，进入细胞质并进行复制。病毒入侵细胞会引起损伤反应、细胞焦亡、免疫细胞浸润、促炎细胞因子（细胞因子风暴）的表达以及适应性免疫系统的激活。根据病毒载量和年龄和基础医疗状况等宿主因素，针对 SARS-CoV-2 的免疫反应可能会导致急性呼吸窘迫综合征 (ARDS)、多器官衰竭和死亡。在这篇综述中，我们指定并证明了可以调节病毒和宿主治疗靶点以缓解症状和治疗疾病。此外，根据世界卫生组织数据库，我们还讨论了大流行期间的疫苗开发以及迄今为止最有希望的候选疫苗。最后，我们讨论了传统的重新利用药物和作为佐剂的潜在替代疗法。
COVID-19 is an infectious respiratory disease caused by SARS-CoV-2, a new beta coronavirus that emerged in Wuhan, China. Being primarily a respiratory disease, it is highly transmissible through both direct and indirect contacts. It displays a range of symptoms in different individuals and thus has been grouped into mild, moderate, and severe diseases. The virus utilizes spike proteins present on its surface to recognize ACE-2 receptors present on the host cells to enter the cell cytoplasm and replicate. The viral invasion of cells induces damage response, pyroptosis, infiltration of immune cells, expression of pro-inflammatory cytokines (cytokine storm), and activation of the adaptive immune system. Depending on viral load and host factors like age and underlying medical conditions, the immune responses mounted against SARS-CoV-2 may cause acute respiratory distress syndrome (ARDS), multiple organ failure, and death. In this review, we specify and justify both viral and host therapeutic targets that can be modulated to relieve the symptoms and treat the disease. Furthermore, we discuss vaccine development in the time of pandemic and the most promising vaccine candidates by far, according to WHO database. Finally, we discuss the conventional re-purposed drugs and potential alternative treatments as adjuvants.
登录
查看更多内容
影响因子：
6.4
作者：
Kaufmann SH
通讯作者：
Kaufmann SH
用糖固醇治疗严重的急性呼吸道综合征：广州体验。
影响因子：
9.6
作者：
Chen RC;Tang XP;Tan SY;Liang BL;Wan ZY;Fang JQ;Zhong N
通讯作者：
Zhong N
影响因子：
13.3
作者：
Al-Horani RA;Desai UR
通讯作者：
Desai UR
影响因子：
--
作者：
Becker, Daniel E
通讯作者：
Becker, Daniel E
影响因子：
56.9
作者：
Chinazzi, Matteo;Davis, Jessica T.;Vespignani, Alessandro
通讯作者：
Vespignani, Alessandro