Diurnal rhythmicity in biological processes involved in bioavailability of functional food factors.
Diurnal rhythmicity in biological processes involved in bioavailability of functional food factors.
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DOI：
10.3164/jcbn.12-127
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发表时间：
2013-05
影响因子：
2.4
通讯作者：
Shimoi K
中科院分区：
文献类型：
--
作者：
Tsurusaki T;Sakakibara H;Aoshima Y;Yamazaki S;Sakono M;Shimoi K
在过去的几十年里，人们在膳食食品中发现了许多类型的功能因子；例如，类黄酮是广泛分布于植物界的主要类别。然而，功能性食品因子的吸收率通常较低，并且由于吸收过程中的生物过程代谢，其中许多难以以完整形式被吸收。因此，为了获得足够的有益效果，必须了解功能性食品因子是否被足够量的吸收，然后到达靶器官，同时保持有益效果。这就是为什么使用啮齿动物模型对功能性食品因子的生物利用度进行了深入研究的原因。最近，据报道，许多生物过程遵循每 24 小时重复一次的昼夜节律。因此，受生物过程影响的功能性食品因子的吸收和代谢可能随一天中的时间而变化。因此，使用啮齿动物模型评估功能性食品因子的生物利用度应考虑食用时间。在这篇综述中，我们对功能性食品因子（特别是类黄酮）的生物利用度所涉及的生物过程的昼夜节律进行了透视概述。
In the past few decades, many types of functional factors have been identified in dietary foods; for example, flavonoids are major groups widely distributed in the plant kingdom. However, the absorption rates of the functional food factors are usually low, and many of these are difficult to be absorbed in the intact forms because of metabolization by biological processes during absorption. To gain adequate beneficial effects, it is therefore mandatory to know whether functional food factors are absorbed in sufficient quantity, and then reach target organs while maintaining beneficial effects. These are the reasons why the bioavailability of functional food factors has been well investigated using rodent models. Recently, many of the biological processes have been reported to follow diurnal rhythms recurring every 24 h. Therefore, absorption and metabolism of functional food factors influenced by the biological processes may vary with time of day. Consequently, the evaluation of the bioavailability of functional food factors using rodent models should take into consideration the timing of consumption. In this review, we provide a perspective overview of the diurnal rhythm of biological processes involved in the bioavailability of functional food factors, particularly flavonoids.
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