The role of tissue factor and factor VIIa in hemostasis.
The role of tissue factor and factor VIIa in hemostasis.
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DOI：
10.1213/ane.0b013e31819bceb1
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发表时间：
2009-05
影响因子：
5.7
通讯作者：
Mackman N
中科院分区：
文献类型：
--
作者：
Mackman N
组织因子 (TF) 是因子 VII/VIIa (FVII/VIIa) 的跨膜受体。它由血管周围的细胞组成型表达。内皮细胞将这种有效的“激活剂”与其循环配体 FVII/FVIIa 物理分离，并防止凝血级联的不当激活。内皮屏障的破裂导致血管外 TF 的暴露和凝血级联的快速激活。 TF 也在某些组织中表达，例如心脏和大脑，并为这些组织提供额外的止血保护。少量的 TF 也以微粒的形式存在于血液中，这些微粒是源自活化细胞和凋亡细胞的小膜囊泡。在多种疾病中，例如败血症和癌症，微粒 TF 水平会增加，这种所谓的“血源性”TF 可能会导致与这些疾病相关的血栓形成。重组FVIIa已被开发为一种有效的止血药物，用于治疗具有抑制性抗体的血友病患者。此外，它还用于对常规治疗无反应的出血患者。然而，重组FVIIa恢复止血的机制尚未明确。总之，TF:FVIIa复合物对于止血至关重要，重组FVIIa是一种有效的止血药物。
Tissue factor (TF) is a transmembrane receptor for Factor VII/VIIa (FVII/VIIa). It is constitutively expressed by cells surrounding blood vessels. The endothelium physically separates this potent “activator” from its circulating ligand FVII/FVIIa and prevents inappropriate activation of the clotting cascade. Breakage of the endothelial barrier leads to exposure of extravascular TF and rapid activation of the clotting cascade. TF is also expressed in certain tissues, such as the heart and brain, and provides additional hemostatic protection to these tissues. Small amounts of TF are also present in blood in the form of microparticles, which are small membrane vesicles derived from activated and apoptotic cells. Levels of microparticle TF increase in a variety of diseases, such as sepsis and cancer, and this so-called “blood-borne” TF may contribute to thrombosis associated with these diseases. Recombinant FVIIa has been developed as an effective hemostatic drug for the treatment of hemophilia patients with inhibitory antibodies. In addition, it is used for patients with bleeding that do not respond to conventional therapy. However, the mechanism by which recombinant FVIIa restores hemostasis has not been clearly defined. In conclusion, the TF:FVIIa complex is essential for hemostasis and recombinant FVIIa is an effective hemostatic drug.
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影响因子：
2.9
作者：
DAVIE, EW;FUJIKAWA, K;KISIEL, W
通讯作者：
KISIEL, W
DOI：
10.1161/01.atv.12.2.135
发表时间：
1992-02-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
ESMON, CT
通讯作者：
ESMON, CT
影响因子：
20.3
作者：
Butenas, S;Bouchard, BA;Mann, KG
通讯作者：
Mann, KG
DOI：
10.1073/pnas.93.13.6258
发表时间：
1996-06-25
影响因子：
11.1
作者：
Bugge, TH;Xiao, Q;Degen, JL
通讯作者：
Degen, JL
影响因子：
64.8
作者：
Coughlin, SR
通讯作者：
Coughlin, SR