Healing of intestinal inflammation by IL-22.
Healing of intestinal inflammation by IL-22.
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DOI：
10.1002/ibd.22929
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发表时间：
2012-09
影响因子：
4.9
通讯作者：
Mizoguchi, Atsushi
中科院分区：
文献类型：
--
作者：
Mizoguchi, Atsushi
关键词：
IL-10家族细胞因子IL-22具有多种独特的生物学特性，包括：1)靶细胞仅限于天然细胞；2)大肠和小肠的表达模式不同；3)细胞来源的改变取决于多种因素；4)在炎症反应中具有保护性和促炎性介质的双重功能；5)与一些主要的IBD易感基因密切相关。IL-22在肠道中的主要功能是刺激上皮细胞产生多种抗菌蛋白，在肠炎症条件下通过刺激粘蛋白1的产生增强粘液屏障，并通过杯状细胞重建促进上皮再生。通过这些有益的功能，IL-22有助于改善某些类型的实验性慢性结肠炎，这是由Th1或Th2反应介导的。最重要的是，使用功能丧失和功能获得两种方法的研究都清楚地证明了IL-22促进急性肠道损伤的肠道伤口愈合的能力。这些发现突出了IL-22是未来IBD治疗的一个有吸引力和有前景的靶点。另一方面，IL-22生物学领域的巨大进展也表明IL-22途径的机制比先前预测的更复杂。这篇综述文章简要总结了以前和现在关于IL-22的知识，特别是与肠道炎症有关的知识。
An IL-10 family cytokine IL-22 is characterized by several unique biological properties, including 1) the target restricted to innate cells, 2) the distinct expression pattern between large and small intestines, 3) alteration of the cellular source depending on several factors, 4) the dual abilities to serve as protective versus proinflammatory mediators in inflammatory responses, and 5) the close association with some major IBD susceptibility genes. The major functions of IL-22 in the intestine are the stimulation of epithelial cells to produce a wide variety of antibacterial proteins, the reinforcement of mucus barrier through stimulation of mucin 1 production under intestinal inflammatory conditions, and the enhancement of epithelial regeneration with goblet cell restitution. Through these beneficial functions, IL-22 contributes to the improvement of some types of experimental chronic colitis, which are mediated by Th1 or Th2 responses. Most importantly, studies using both loss-of-function and gain-of-function approaches have clearly demonstrated the ability of IL-22 to promote intestinal wound healing from acute intestinal injury. These findings highlight IL-22 as an attractive and promising target for future IBD therapy. Alternatively, the enormous progress in the field of IL-22 biology has also suggested more complicated mechanism with IL-22 pathway than previously predicted. This review article briefly summarizes previous and current knowledge on IL-22 particularly associated with intestinal inflammation.
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影响因子：
64.8
作者：
Cella, Marina;Fuchs, Anja;Vermi, William;Facchetti, Fabio;Otero, Karel;Lennerz, Jochen K. M.;Doherty, Jason M.;Mills, Jason C.;Colonna, Marco
通讯作者：
Colonna, Marco
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
9.8
作者：
Begue, Bernadette;Verdier, Julien;Ruemmele, Frank M.
通讯作者：
Ruemmele, Frank M.
影响因子：
4.4
作者：
Andoh, Akira;Shioya, Makoto;Fujiyama, Yoshihide
通讯作者：
Fujiyama, Yoshihide
影响因子：
4.4
作者：
Chang, He;Hanawa, Haruo;Aizawa, Yoshifusa
通讯作者：
Aizawa, Yoshifusa