Group 1 Metabotropic Glutamate Receptors in Neurological and Psychiatric Diseases: Mechanisms and Prospective.
Group 1 Metabotropic Glutamate Receptors in Neurological and Psychiatric Diseases: Mechanisms and Prospective.
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DOI：
10.1177/10738584211021018
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发表时间：
2022-10
期刊：
影响因子：
5.6
通讯作者：
Shen, Ying
中科院分区：
文献类型：
--
作者：
Su, Li-Da;Wang, Na;Han, Junhai;Shen, Ying
关键词：
代谢型谷氨酸受体（mGluRs）是在中枢神经系统（CNS）中由谷氨酸激活的G蛋白偶联受体。基本上，mGluRs有助于突触功效的微调，并控制神经传递的准确性和锐度。在8种亚型中，mGluR1和mGluR5属于第1组（Gp1）家族，与多种中枢神经系统疾病（如阿尔茨海默病、帕金森病、自闭症等）有关，本文就Gp1 mGluR1在阿尔茨海默病、帕金森病、自闭症谱系障碍、癫痫、亨廷顿氏病、智力残疾、唐氏综合征、Rett综合征、注意力缺陷多动障碍、成瘾、焦虑、伤害感受、精神分裂症和抑郁症，以便提供对Gp1 mGluR的治疗潜力的更多了解。
Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that are activated by glutamate in the central nervous system (CNS). Basically, mGluRs contribute to fine-tuning of synaptic efficacy and control the accuracy and sharpness of neurotransmission. Among eight subtypes, mGluR1 and mGluR5 belong to group 1 (Gp1) family, and are implicated in multiple CNS disorders, such as Alzheimer’s disease, autism, Parkinson’s disease, and so on. In the present review, we systematically discussed underlying mechanisms and prospective of Gp1 mGluRs in a group of neurological and psychiatric diseases, including Alzheimer’s disease, Parkinson’s disease, autism spectrum disorder, epilepsy, Huntington’s disease, intellectual disability, Down’s syndrome, Rett syndrome, attention-deficit hyperactivity disorder, addiction, anxiety, nociception, schizophrenia, and depression, in order to provide more insights into the therapeutic potential of Gp1 mGluRs.
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