Sleep Polygenic Risk Score Is Associated with Cognitive Changes over Time.
Sleep Polygenic Risk Score Is Associated with Cognitive Changes over Time.
复制标题
睡眠多基因风险评分与随着时间推移的认知变化有关。
DOI：
10.3390/genes13010063
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发表时间：
2021-12-27
期刊：
影响因子：
3.5
通讯作者：
Scarmeas N
中科院分区：
文献类型：
--
作者：
Tsapanou A;Mourtzi N;Charisis S;Hatzimanolis A;Ntanasi E;Kosmidis MH;Yannakoulia M;Hadjigeorgiou G;Dardiotis E;Sakka P;Stern Y;Scarmeas N
从横向和纵向上看，睡眠问题都与认知有关。特定的基因也与睡眠调节和认知有关。在一大群老年非痴呆成年人中，我们的目的是(a)验证睡眠多基因风险评分（Sleep PRS）与自我报告的睡眠时间之间的关联，(b)在为期三年的随访中检查睡眠多基因风险评分与认知变化之间的关联。参与者来自希腊老龄化和饮食纵向调查（HELIAD）。在每次访问期间（基线和第一次随访），对每位参与者进行结构化的面对面访谈，包括病史报告和体格检查。总共包括1376名参与者，他们拥有所有的人口统计、遗传和认知数据，其中688人至少有一次随访。此外，还进行了广泛的神经心理学评估，检查了五个认知领域（记忆、视觉空间能力、注意力/处理速度、执行功能和语言）。睡眠时间的PRS是基于先前发表的全基因组关联研究荟萃分析结果创建的。为了评估睡眠PRS与认知变化速率之间的关系，我们使用了广义估计方程分析。以年龄、性别、受教育程度、载脂蛋白-ε4基因型状态和特定主成分为协变量。在进一步的分析中，睡眠药物被用作进一步的协变量。结果证实了睡眠PRS与自我报告睡眠持续时间之间的关联（B = 1.173, E-6, p = 0.001）。此外，在纵向分析中，在未调整（B = - 1305.220, p = 0.018）和调整协变量模型（B = - 1273.59, p = 0.031）中，睡眠PRS增加与视觉空间能力下降之间存在显著关联。同样，在添加睡眠药物作为协变量后（B = - 1372.46, p = 0.019），睡眠PRS与其余认知领域之间的关联均不显著。PRS表明，随着时间的推移，在一组非痴呆的老年人中，较长的睡眠时间与不同的认知衰退率有关。常见的基因变异可能影响睡眠时间与健康衰老/认知健康之间的关系。
Sleep problems have been associated with cognition, both cross-sectionally and longitudinally. Specific genes have been also associated with both sleep regulation and cognition. In a large group of older non-demented adults, we aimed to (a) validate the association between Sleep Polygenic Risk Score (Sleep PRS) and self-reported sleep duration, and (b) examine the association between Sleep PRS and cognitive changes in a three-year follow-up. Participants were drawn from the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD). A structured, in-person interview, consisting of a medical history report and physical examination, was conducted for each participant during each of the visits (baseline and first follow-up). In total, 1376 participants were included, having all demographic, genetic, and cognitive data, out of which, 688 had at least one follow-up visit. In addition, an extensive neuropsychological assessment examining five cognitive domains (memory, visuo-spatial ability, attention/speed of processing, executive function, and language) was administered. A PRS for sleep duration was created based on previously published, genome-wide association study meta-analysis results. In order to assess the relationship between the Sleep PRS and the rate of cognitive change, we used generalized estimating equations analyses. Age, sex, education, ApolipoproteinE-ε4 genotype status, and specific principal components were used as covariates. On a further analysis, sleep medication was used as a further covariate. Results validated the association between Sleep PRS and self-reported sleep duration (B = 1.173, E-6, p = 0.001). Further, in the longitudinal analyses, significant associations were indicated between increased Sleep PRS and decreased visuo-spatial ability trajectories, in both the unadjusted (B = −1305.220, p = 0.018) and the adjusted for the covariates model (B = −1273.59, p = 0.031). Similarly, after adding sleep medication as a covariate (B = −1372.46, p = 0.019), none of the associations between Sleep PRS and the remaining cognitive domains were significant. PRS indicating longer sleep duration was associated with differential rates of cognitive decline over time in a group of non-demented older adults. Common genetic variants may influence the association between sleep duration and healthy aging/cognitive health.
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